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Regulation of Vascular Graft Healing by Induction of Tissue Incorporation

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Human Biomaterials Applications

Abstract

The phrase vascular graft healing implies the encapsulation of prosthetic material by host tissue. Healing occurs at the external surface, interstitium, and luminal surface of the graft, and results in the presence of living cells and acellular stroma in and around the prostheses. Investigators have characterized the end results of this process in response to numerous prosthetic materials over the course of four decades. Until recently, the guiding premise has been that biomaterials should be biologically inert. No truly inert material has yet been developed. Clinical results using currently available biomaterials have been disappointing, especially in the arena of small diameter vascular grafts. An alternative philosophical approach, which has been the topic of recent investigation, involves optimization of the tissue—biomaterial interaction to enlist the natural healing process to cooperate in the formation of the ideal vascular conduit.

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Authors
  1. Howard P. Greisler
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Editors and Affiliations

  1. Northeastern University, Boston, MA, USA

    Donald L. Wise PhD

  2. Cambridge Scientific, Inc., Belmont, MA, USA

    Debra J. Trantolo PhD  & Joseph D. Gresser PhD  & 

  3. Harvard School of Dental Medicine, Boston, MA, USA

    David E. Altobelli DMD, MD

  4. USAF Medical Center, Lackland AFB, TX, USA

    Michael J. Yaszemski MD, PhD

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Greisler, H.P. (1996). Regulation of Vascular Graft Healing by Induction of Tissue Incorporation. In: Wise, D.L., Trantolo, D.J., Altobelli, D.E., Yaszemski, M.J., Gresser, J.D. (eds) Human Biomaterials Applications. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2487-5_17

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  • DOI: https://doi.org/10.1007/978-1-4757-2487-5_17

  • Publisher Name: Humana Press, Totowa, NJ

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