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Slow Release of an LHRH Analog to Reduce Serum Testosterone

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Human Biomaterials Applications

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Abstract

During the last several decades, research into neuroendocrine control by LHRH and other hypothalamic hormones has been an area of high activity. Since Schally and Guillemin’s Nobel Prize winning work of the early 1970s, the isolation, determination of structure, and synthesis of hypothalamic peptide hormones, as well as the synthesis of their analogs, have revealed radically new approaches to diagnosis and treatment of endocrine and nonendocrine disorders (1–10). Clinical applications of the hypothalamic hormones include: differentiation between hypothalamic and pituitary lesion, stimulation of fertility, birth control, and treatment of precocious puberty, endometriosis, cryptochidism, diabetes mellitus, acromegaly, and acute pancreatitis. The uses of analogs of hypothalamic hormones for hormone-sensitive tumors is relatively more recent, but of major current clinical value and significance, as evidenced by the quick transfer of basic research results to FDA approvals. LHRH agonist analogs are now used for the treatment of endometriosis and precocious puberty, as well as many of the endocrine-dependent tumors found in prostate cancer, breast cancer, and ovarian cancer.

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Authors
  1. Debra J. Trantolo
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  2. Joseph D. Gresser
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  3. A. Ganiyu Jimoh
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  4. Donald L. Wise
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  5. Richard C. Rhodes III
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  6. Janet E. Hall
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Editor information

Editors and Affiliations

  1. Northeastern University, Boston, MA, USA

    Donald L. Wise PhD

  2. Cambridge Scientific, Inc., Belmont, MA, USA

    Debra J. Trantolo PhD  & Joseph D. Gresser PhD  & 

  3. Harvard School of Dental Medicine, Boston, MA, USA

    David E. Altobelli DMD, MD

  4. USAF Medical Center, Lackland AFB, TX, USA

    Michael J. Yaszemski MD, PhD

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© 1996 Springer Science+Business Media New York

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Trantolo, D.J., Gresser, J.D., Jimoh, A.G., Wise, D.L., Rhodes, R.C., Hall, J.E. (1996). Slow Release of an LHRH Analog to Reduce Serum Testosterone. In: Wise, D.L., Trantolo, D.J., Altobelli, D.E., Yaszemski, M.J., Gresser, J.D. (eds) Human Biomaterials Applications. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2487-5_16

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  • DOI: https://doi.org/10.1007/978-1-4757-2487-5_16

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-012-0

  • Online ISBN: 978-1-4757-2487-5

  • eBook Packages: Springer Book Archive

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