Skin Repair with Cultured Cells and Biopolymers

  • Steven T. Boyce


Skin loss injuries resulting from burns, traumatic injury, or congenital or acquired disease cause acute and chronic disability exceeding $1 billion in the United States (1), including approximately two million hospital days annually from burns (2–4). Earlier wound closure with full restoration of function may hypothetically reduce this socioeconomic cost. Conventional treatment accomplishes restoration of function with meshed or unmeshed split-thickness skin graft (S,6). However, harvesting of donor skin inflicts additional injury, and long-term recovery after skin grafting of burns often includes multiple reconstructive procedures (7, 8). Furthermore, conditions in which skin grafting is not possible (i.e., large burns) or not recommended (i.e., chronic wounds in high-risk patients) have stimulated studies directed toward availability of alternative materials for closure of full-thickness skin wounds. A common objective of alternative materials for skin repair is restoration of all anatomic structures and physiologic functions of skin, including epidermal barrier, fibrovascular tissue, pigment, immune function, sensation, ther moregulation, full range ofmotion, and acceptable cosmesis. Each of these functions depends on restoration of tissue structure, which consists of parenchymal cells, immune cells, and extracellular mediators. Mediators include soluble and insoluble factors that generally define cytokines and matrix, respectively. Scar formation may be considered excessive deposition of collagenous matrix that is related inversely to the quality of functional and cosmetic outcome.


Skin Substitute Epidermal Barrier Dermal Substitute Skin Analog Autologous Keratinocytes 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 1996

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  • Steven T. Boyce

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