Multiphasic or “Pulsatile” Controlled Release System for the Delivery of Vaccines

  • Otute Akiti
  • A. Ganiyu Jimoh
  • Donald L. Wise
  • Gilda A. Barabino
  • Debra J. Trantolo
  • Joseph D. Gresser


Controlled drug release refers to the technique of drug administration whereby a reservoir delivers drug to a host. Such a system releases the required drug at some rate for a predetermined period of time. The origins of controlled drug release can be traced as far back as 1000 yr ago. Rhazes (850–923) recommended mucilage coating of pills using an extract ofpsyllium, and Avicenna (980–1037) recommended silvering and gilding pills (1). The silvering and gilding technology found its way to Europe, where the nobility enjoyed the luxury of pills coated with silver or gold. Although the coatings served primarily to mask the taste of the bitter tasting agents, they nevertheless altered the release kinetics of the drugs they enveloped.


Membrane Thickness Delivery Device Malaria Vaccine Control Drug Release Insulin Delivery 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Otute Akiti
  • A. Ganiyu Jimoh
  • Donald L. Wise
  • Gilda A. Barabino
  • Debra J. Trantolo
  • Joseph D. Gresser

There are no affiliations available

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