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Hormonal Regulation of Liver Cytochrome P450 Enzymes

  • Chapter
Cytochrome P450

Abstract

Endogenous steroids and other naturally occurring lipophilic substances serve as important substrates for cytochrome P450 (CYP) enzymes found in liver and other tissues,1,2 including the primary steroidogenic tissues (Kagawa and Waterman, this volume). Steroid hormones are metabolized by liver P450 enzymes with a higher degree of regio-and stereoselectivity than many foreign compound substrates,3 suggesting that these endogenous lipophiles serve as physiological P450 substrates. Eight of the twelve mammalian P450 gene families described as of 19934 encode enzymes that catalyze steroid hydroxylations. Two of these gene families (CYP2 and CYP3) encode liver P450 enzymes required for the hydroxylation of steroid hormones and bile acids, and two encode P450s that participate in the conversion of cholesterol to bile acids in the liver, where they contribute in a major way to cholesterol homeostasis (CYP7, CYP27).5

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  1. Division of Cell and Molecular Biology, Department of Biology, Boston University, Boston, Massachusetts, 02215, USA

    David J. Waxman

  2. Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada

    Thomas K. H. Chang

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  1. Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, 94143, San Francisco, California, USA

    Paul R. Ortiz de Montellano

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Waxman, D.J., Chang, T.K.H. (1995). Hormonal Regulation of Liver Cytochrome P450 Enzymes. In: de Montellano, P.R.O. (eds) Cytochrome P450. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2391-5_11

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