Wilms Tumor-Susceptibility Loci

  • Vicki Huff
Part of the Contemporary Biomedicine book series (CB, volume 12)


Nephroblastoma, or Wilms tumor (WT), is a childhood tumor of the kidney that was described and characterized in several case reports and reviews during the 19th century. It acquired its commonly used eponym after Max Wilms published a monograph on the subject in 1899. Occurring with a frequency of roughly 1 in 10,000 live births (Matsunaga, 1981; Breslow et al., 1983), WT is one of the most common solid tumors of children. Fortunately, it is also one of the most successfully treated childhood cancers; with a triple modality therapy of surgery, chemotherapy, and radiotherapy, the overall 2-yr, disease-free survival rate is now 85% (D’Angio et al., 1989).


Zinc Finger Domain Maternal Allele Embryonal Tumor Fetal Kidney Beckwith Wiedemann Syndrome 
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  1. Ali, I. U., R. Lidereau, C. Theillet, and R. Callahan (1987), Science 238, 185–188.PubMedCrossRefGoogle Scholar
  2. Bartolomei, M. S., S. Zemel, and S. M. Tilghman (1991), Nature 351, 153–155.PubMedCrossRefGoogle Scholar
  3. Beckwith, J. B. (1969), Birth Defects 5, 188–190.Google Scholar
  4. Beckwith, J. B. (1989) in Renal Pathology, vol. II (Tisher, C. C. and B. M. Brenner, eds.), J. B. Lippincott, Philadelphia, pp. 1438–1466.Google Scholar
  5. Beckwith, J. B., N. B. Kiviat and J. F. Bonadio (1990), Pediatr. Pathol. 10, 1–36.PubMedCrossRefGoogle Scholar
  6. Bickmore, W. A., K. Oghene, M. H. Little, A. Seawright, V. van Heyningen, N. D. and Hastie (1992), Science 257, 235–237.PubMedCrossRefGoogle Scholar
  7. Bonetta, L., S. E. Kuehn, A. Huang, D. J. Law, L. M. Kalikin, M. Koi, A. E. Reeve, B. H. Brownstein, H. Yeger, B. R. G. Williams and A. P. Feinberg (1990), Science 250, 994–997.PubMedCrossRefGoogle Scholar
  8. Bove, K. E., H. Koffler and A. J. McAdams (1969), Cancer 24, 323–332.PubMedCrossRefGoogle Scholar
  9. Breslow, N. E. and J. B. Beckwith (1982), J. Natl. Cancer Instit. 68, 429–436.Google Scholar
  10. Breslow, N. E. and B. Langholz (1983), Int. l. Cancer 32, 703–716.CrossRefGoogle Scholar
  11. Breslow, N. E., J. B. Beckwith, M. Ciol, and K. Sharples (1988), Cancer Res. 48, 1653–1657.PubMedGoogle Scholar
  12. Breslow, N., A. Olshan J. B. Beckwith, and D. Green (1992), Med. Pediatr. Oncol. 21, 172–181.CrossRefGoogle Scholar
  13. Brown, W. T., S. R. Purnaik, D. H. Altman, and H. C. Hardin (1972), Surgery 72, 756–761.PubMedGoogle Scholar
  14. Brown, K. W., J. E. Watson, V. Poirier, M. G. Mott, P. J. Berry, and N. J. Maitland (1992), Oncogene 7, 763–768.PubMedGoogle Scholar
  15. Brunkow, M. E. and S. M. Tilghman (1991), Genes Devel. 5, 1092–1101.PubMedCrossRefGoogle Scholar
  16. Call, K. M., T. Glaser, C. Y. Ito, A. J. Buckler, J. Pelletier, D. A. Haber, E. A. Rose, A. Kral, H. Yeger, W. H. Lewis, C. Jones, and D. E. Housman (1990), Cell 60, 509–520.PubMedCrossRefGoogle Scholar
  17. Chao, L.-Y., V. Huff, G. Tomlinson, V. M. Riccardi, L. C. Strong, and G. F. Saunders (1993), Nature Genet. 3, 127–131.PubMedCrossRefGoogle Scholar
  18. Compton, D. A., M. M. Weil, C. Jones, V. M. Riccardi, L. C. Strong, and G. F. Saunders (1988), Cell 55, 827–836.PubMedCrossRefGoogle Scholar
  19. Compton, D. A., M. M. Weil, L. Bonetta, A. Huang, C. Jones, H. Yeger, B. R. G. Williams L. C. Strong, and G. F. Saunders (1990), Genomics 6, 309–315.PubMedCrossRefGoogle Scholar
  20. Cowell, J. K., R. B. Wadey, D. A. Haber, K. M. Call, D. E. Housman, and J. Pritchard (1991), Oncogene 6, 595–599.PubMedGoogle Scholar
  21. D’Angio G. J., N. Breslow, J. B. Beckwith, A. Evans, E. Baum, A. deLorimier, D. Fernback, E. Hrabovsky, B. Jones, P. Kelalis, H. B. Othersen, M. Tefft, and P. R. M. Thomas (1989), Cancer 64, 349–360.PubMedCrossRefGoogle Scholar
  22. Dao, D. D., W. T. Schroeder, L.-Y. Chao, H. Kikuchi, L. C. Strong, V. M. Riccardi, S. Pathak, W. W. Nichols, W. H. Lewis, and G. F. Saunders (1987), Am. J. Hum. Genet. 41, 202–217.PubMedGoogle Scholar
  23. Davis, L. M., R. Stallard, G. H. Thomas, P. Couillin, C. Junien, N. J. Nowak, and T. B. Shows (1988), Science 241, 840–842.PubMedCrossRefGoogle Scholar
  24. DeChiara, T. M., E. J. Robertson, and A. Efstratiadis (1991), Cell 64, 849–859.PubMedCrossRefGoogle Scholar
  25. Dowdy, S. F., C. L. Fasching, D. Araujo, K.-M. Lai, E. Livanos, B. E. Weissman, and E. J. Stanbridge, E. J. (1991), Science 254, 293–295.PubMedCrossRefGoogle Scholar
  26. Drummond, I. A., S. L. Madden, P. Rohwer-Nutter, G. Bell, V. P. Sukhatme, and F. J. Rauscher, III (1992), Science 257, 674–678.Google Scholar
  27. Fearon, E. R., B. Vogelstein, and A. Feinberg (1984), Nature 309, 176–178.PubMedCrossRefGoogle Scholar
  28. Fearon, E. R., A. P. Feinberg, S. H. Hamilton, and B. Vogelstein (1985), Nature 318, 377–380.PubMedCrossRefGoogle Scholar
  29. Francke, U. (1990), Nature 343, 692–694.PubMedCrossRefGoogle Scholar
  30. Fraumeni, J. F. and A. G. Glass (1968), JAMA 206, 825–828.PubMedCrossRefGoogle Scholar
  31. Fraizer, G. C., Y. J. Wu, S. M. Hewitt, T. Maity, C. Ton, V. Huff and G. F. Saunders (1993a), Mol. Biol. Cell. 269, 8092–8900.Google Scholar
  32. Fraizer, G. C., S. M. Hewitt, Y. J. Wu, T. Maity and G. F. Saunders (1993b), Proc. Am. Assoc. Cancer Res. (Abstract).Google Scholar
  33. Garvin, A. J., G. G. Re, B. I. Tarnowski, D. J. Hazen-Martin, and D. A. Sens (1993), Am. J. Pathol. 142, 375–380.Google Scholar
  34. Gashler, A. L., D. T. Bonthron, S. L. Madden, F. J. Rauscher, III, T. Collins and V. P. Sukhatme (1992), Proc. Natl. Acad. Sci. USA 89 10,984–10,988.Google Scholar
  35. Gessler, M., Konig, A., and Bruns, G. A. P. (1992), Genomics 12, 807–813.PubMedCrossRefGoogle Scholar
  36. Gessler, M. and G. A. P. Bruns (1988), Genomics 3, 117–123.PubMedCrossRefGoogle Scholar
  37. Gessler, M., A. Proustka, W. Cavenee, R. L. Neve, S. H. Orkin, and G. A. P. Bruns (1990), Nature 343, 774–778.PubMedCrossRefGoogle Scholar
  38. Gessler, M., G. H. Thomas, P. Couillin, C. Junien, B. C. McGillivray, M. Hayden, F. Jaschek, and G. A. P. Bruns (1989), Am. J. Hum. Genet. 44, 486–495.Google Scholar
  39. Gilbert, S. F. (1991), Developmental Biology, 3rd ed., Sinauer, Sunderland, MA, pp. 582–586.Google Scholar
  40. Grundy, P., A. Koufos, K. Morgan, F. P. Li, A. T. Meadows, and W. K. Cavenee (1988), Nature 336, 374–376.PubMedCrossRefGoogle Scholar
  41. Haber, D. A., R. L. Sohn, A. J. Buckler, J. Pelletier, K. M. Call, and D. E. Housman (1991), Proc. Natl. Acad. Sci. USA 88, 9618–9622.PubMedCrossRefGoogle Scholar
  42. Haber, D. A., A. J. Buckler, T. Glaser, K. M. Call, J. Pelletier, R. L. Sohn, E. C. Douglass, and D. E. Housman (1990), Cell 61, 1257–1269.PubMedCrossRefGoogle Scholar
  43. Haselbacher, G. K., J.-C. Irminger, J. Zapf, W. H. Ziegler, and R. E. Humbel (1987), Proc. Natl. Acad. Sci. USA 84, 1104–1106.PubMedCrossRefGoogle Scholar
  44. Hayashi, H., R. Hanad, K. Yamamoto, and H. Muchi (1988), Cancer Genet. Cytogenet. 33, 145–147.PubMedCrossRefGoogle Scholar
  45. Henry, I. S. Grandjouan, P. Couillin, F. Barichard, C. Huerre-Jeanpierre, T. Glaser, T. Philip, G. Lenoir, J. L. Chaussain, and C. Junien (1989), Proc. Natl. Acad. Sci. USA 86 3247–3251.Google Scholar
  46. Henry, I., C. Bonaiti-Pellie, V. Chehensse, C. Beldjord, C. Schwartz, G. Utermann, and C. Junien, (1991), Nature 351, 665–667.PubMedCrossRefGoogle Scholar
  47. Hittner, H. M., V. M. Riccardi, and U. Francke (1979), Ophthamology 86, 1173–1183.Google Scholar
  48. Huang, A., C. E. Campbell, L. Bonetta, M. S. McAndrews-Hill, S. Chilton-MacNeill, M. J. Coppes, D. J. Law, A. P. Feinberg, H. Yeger, and B. R. G. Williams (1990), Science 250, 991–994.PubMedCrossRefGoogle Scholar
  49. Huff, V., A. Meadows, V. M. Riccardi, L. C. Strong, and G. F. Saunders (1990) Am. J. Hum. Genet. 47, 155–160PubMedGoogle Scholar
  50. Huff, V., D. A. Compton, L.-Y. Chao, L. C. Strong, C. F. Geiser, and G. F. Saunders (1988), Nature 336, 377, 378.Google Scholar
  51. Huff, V., H. Miwa, D. A. Haber, K. Call, K. M. Housman, L. C. Strong, and G. F. Saunders, (1991a), Am. J. Hum. Genet. 48, 997–1003.PubMedGoogle Scholar
  52. Huff, V., F. Villalba, V. M. Riccardi, L. C. Strong, and G. F. Saunders (1991b), Am. J. Hum. Genet. Suppl. 49, 44.Google Scholar
  53. Huff, V., A. E. Reeve, M. Leppert, L. C. Strong, E. C. Douglass, D. F. Geiser, F. P. Li, A. Meadows, D. F. Callen, G. Lenoir, and G. F. Saunders (1992), Cancer Res. 52, 6117–6120.PubMedGoogle Scholar
  54. Kaneko, Y., M. C. Egues, and J. D. Rowley (1981), Cancer Res. 4577–4578.Google Scholar
  55. Kikuchi, H., Y. Akasaka, T. Nagai, A. Umezawa, H. Iri, S. Kato, and J. Hata (1992), Am. J. Pathol. 140, 781–786.Google Scholar
  56. Knudson, A. G. and L. C. Strong (1972), J. Natl. Cancer Inst. 48, 313–324.PubMedGoogle Scholar
  57. Koufos, A., M. F. Hansen, N. G. Copeland, N. A. Jenkins, B. C. Lampkin, and W. Cavenee (1985), Nature 316, 330–334.PubMedCrossRefGoogle Scholar
  58. Koufos, A., M. F. Hansen, B. C. Lampkin, M. L. Workman, N. B. Copeland, N. A. Jenkins, and W. K. Cavenee (1984), Nature 309, 170–172.PubMedCrossRefGoogle Scholar
  59. Koufos, A., P. Grundy, K. Morgan, K. A. Aleck, T. Hadro, B. C. Lampkin, A. Kalbakji, and W. K. Cavenee (1989), Am. J. Hum. Genet. 44, 711–719.PubMedGoogle Scholar
  60. Kousseff, B. G. and A. Agatucci (1981), J. Pediatr. 96, 676–678.Google Scholar
  61. Lavedan, C., F. Barichard, M. Azoulay, P. Couillin, D. Molina Gomez, H. Nicolas, B. Quack, M. O. Rethore, B. Noel, and C. Junien (1989), Cytogenet. Cell. Genet. 50, 70–74.PubMedCrossRefGoogle Scholar
  62. Lewis, W. H., H. Yeger, L. Bonetta, H. S. L. Chan, J. Kang, C. Junien, J. Cowell, C. Jones, and L. A. Dafoe (1988), Genomics 3, 25–31.PubMedCrossRefGoogle Scholar
  63. Little, M. H., D. B. Thomson, N. K. Hayward, and P. J. Smith (1988), Hum. Genet. 79, 186–189.PubMedCrossRefGoogle Scholar
  64. Little, M. H., R. Dunn, J. A. Byrne, A. Seawright, P. J. Smith, K. Pritchard-Jones, V. van Heyningen, and N. D. Hastie (1992a), Oncogene 7, 635–641.PubMedGoogle Scholar
  65. Little, M. H., J. Prossner, A. Condie, P. J. Smith, V. van Heyningen and N. D. Hastie (1992b), Proc. Natl. Acad. Sci. USA 89, 4791–4795.PubMedCrossRefGoogle Scholar
  66. Lothe, R. A., S. D. Fossa, A. E. Stenwig, Y. Nakamura, R. White, A.-L. Borresen, and A. Brogger (1989), Genomics 5, 134–138.PubMedCrossRefGoogle Scholar
  67. Madden, S. L., D. M. Cook, J. F. Morris, A. Gashler, V. P. Sukhatme, and F. Rauscher, III (1991) Science 253, 1550–1553.Google Scholar
  68. Mannens, M., P. Devilee, J. Bliek, I. Mandjes, J. de Kraker, C. Heyting, R. M. Slater, and A. Westerveld (1990) Cancer Res. 50, 3279–3283.PubMedGoogle Scholar
  69. Mannens, M., R. M. Slater, C. Heyting, J. Bliek, J. de Kraker, N. Coad, P. de PagterHolthuizen, and P. L. Pearson (1988), Hum. Genet. 81, 41–48.PubMedCrossRefGoogle Scholar
  70. Matsunaga, E. (1981), Hum. Genet. 57, 231–246.PubMedCrossRefGoogle Scholar
  71. Maw, M., P. E. Grundy, L. J. Millow, M. R. Eccles, R. S. Dunn, P. J. Smith, A. P. Feinberg, D. J. Law, M. C. Paterson, P. E. Telzerow, D. F. Callen, A. D. Thompson, R. I. Richards, and A. E. Reeve (1992), Cancer Res. 52, 3094–3098.PubMedGoogle Scholar
  72. Miller, R. W., J. F. Fraumeni, Jr., and M. D. Manning (1964), NEJM 270, 922–927.PubMedCrossRefGoogle Scholar
  73. Miwa, H., M. Beran, and G. F. Saunders (1992a), Leukemia 6, 405–409.PubMedGoogle Scholar
  74. Miwa, H., G. E. Tomlinson, C. Timmons, V. Huff, S. L. Cohn, L. C. Strong, and G. F. Saunders (1992b), Cancer Res. 84, 181–187.Google Scholar
  75. Nakagome, Y. and N. Nagahara (1985), Hum. Genet. 70, 289.PubMedCrossRefGoogle Scholar
  76. Narod, S. A. and G. M. Lenoir (1991), Internatl. J. Epidem. 20, 346–348.CrossRefGoogle Scholar
  77. Ogawa, O., M. R. Eccles, K. Yun, K., R. F. Mueller, M. D. D. Holdaway, and A. Reeve (1993), Human Mole. Genet. 2, 203, 204.Google Scholar
  78. Olshan, A. F. (1986), Cancer Genet. Cytogenet. 21, 303–307.PubMedCrossRefGoogle Scholar
  79. Orkin, S. H., D. S. Goldman, and S. E. Sallan (1984), Nature 309, 172–174.PubMedCrossRefGoogle Scholar
  80. Pelletier, J., W. Bruening, C. D. Kashtan, S. M. Mauer, J. C. Manivel, J. E. Striegel, D. C. Houghton, C. Junien, R. Habib, L. Fouser, R. N. Fine, B. L. Silverman, D. A. Haber, and D. E. Housman (1991a), Cell 67, 437–447.PubMedCrossRefGoogle Scholar
  81. Pelletier, J., W. Bruening, F. P. Li, D. A. Haber, T. Glaser, and D. E. Housman (1991b), Nature 353 431–434.Google Scholar
  82. Pelletier, J., M. Schalling, A. J. Buckler, A. Rogers, D. A. Haber, and D. Housman (1991c), Genes Dev. 5, 1345–1356.PubMedCrossRefGoogle Scholar
  83. Ping, A. J., A. E. Reeve, D. J. Law, M. R. Young, M. Boehnke, and A. P. Feinberg (1989), Am. J. Hum. Genet. 44, 720–723.PubMedGoogle Scholar
  84. Poirer, F., C.-T. J. Chan, P. M. Timmons, E. J. Robertson, M. J. Evans, and P. W. J. Rigby, (1991), Development 113, 1105–1114.Google Scholar
  85. Porteous, D. J., W. Bickmore, S. Christie, P. A. Boyd, G. Cranston, J. M. Fletcher, J. R. Gosden, D. Rout, A. Seawright, K. O. J. Simola, V. van Heyningen, and N. D. Hastie (1987), Proc. Natl. Acad. Sci. USA 84, 5355–5359.PubMedCrossRefGoogle Scholar
  86. Pritchard-Jones, K. and S. Fleming (1991), Oncogene 6, 2211–2220.PubMedGoogle Scholar
  87. Pritchard-Jones, K., S. Fleming, D. Davidson, W. Bickmore, D. Porteous, C. Gosden, J. Bard, A. Buckler, J. Pelletier, D. Housman, V. van Heyningen, and N. Hastie (1990), Nature 346, 194–196.PubMedCrossRefGoogle Scholar
  88. Rachmilewitz, J., R. Goshen, I. Ariel, T. Schneider, N. de Groot, and A. Hochberg (1992), FEBS Lett. 309, 25–28.PubMedCrossRefGoogle Scholar
  89. Raizis, A. M., D. M. Becroft, R. Shaw, and A. E. Reeve (1985), Hum. Genet. 70, 344–346.PubMedCrossRefGoogle Scholar
  90. Rauscher, F. J., III, J. F. Morris, O. E. Tournay, D. M. Cook, and T. Curran (1990), Science 250, 1259–1262.PubMedCrossRefGoogle Scholar
  91. Reeve, A. E., S. A. Sih, A. M. Raizis, and A. P. Feinberg, A. P. (1989), Mol. Cell. Biol. 9, 1799–1803.PubMedGoogle Scholar
  92. Reeve, A. E., M. R. Eccles, R. J. Wilkins, G. I. Bell, and L. J. Millow (1985), Nature 317, 258–260.PubMedCrossRefGoogle Scholar
  93. Reeve, A. E., P. J. Housiaux, R. J. M. Gardner, W. E. Chewings, R. M. Grindley, and L. J. Millow (1984), Nature 309, 174–176.PubMedCrossRefGoogle Scholar
  94. Reik, W. and M. A. Surani (1989), Nature 338, 112, 113.Google Scholar
  95. Riccardi, V. M., E. Sujansky, A. C. Smith, and U. Francke (1978), Pediatrics 61, 604–610.PubMedGoogle Scholar
  96. Riccardi, V. M., H. M. Hittner, U. Francke, J. J. Yunis, D. Ledbetter, and W. Borges (1980), Cancer Genet. Cytogenet. 2, 131–138.CrossRefGoogle Scholar
  97. Rose, E. A., T. Glaser, C. Jones, C. L. Smith, W. H. Lewis, K. M. Call, M. Minden, E. Champagne, L. Bonetta, H. Yeger, and D. E. Housman (1990), Cell 60, 495–508.PubMedCrossRefGoogle Scholar
  98. Schroeder, W. T., L.-Y. Chao, D. D. Dao, L. C. Strong, S. Pathak, V. Riccardi, W. H. Lewis, and G. F. Saunders (1987), Am. J. Hum. Genet.. 40 413–420.Google Scholar
  99. Schwarz, C. E., D. A. Haber, V. P. Stanton, L. C. Strong, M. H. Skolnick, and D. E. Housman, (1991), Genomics 10, 927–930.CrossRefGoogle Scholar
  100. Scott, J., J. Cowell, M. E. Robertson, L. M. Priestly, R. Wadey, B. Hopkins, J. PritchardGoogle Scholar
  101. G. I. Bell, L. B. Rall, C. F. Graham, and T. J. Knott (1985), Nature 317, 260–262.PubMedCrossRefGoogle Scholar
  102. Scrable, H. J., D. P. Witte, B. C. Lampkin, and W. K. Cavenee (1987), Nature 329, 645–647.PubMedCrossRefGoogle Scholar
  103. Scrable, H., W. Cavenee, F. Ghavimi, M. Lovell, K. Morgan, and C. Sapienza (1989), Proc. Natl. Acad. Sci. USA 86, 7480–7484.PubMedCrossRefGoogle Scholar
  104. Solis, V., J. Pritchard, and J. K. Cowell (1988), Cancer Genet. Cytogenet. 34, 223–234.PubMedCrossRefGoogle Scholar
  105. Sotelo-Avila, C., F. Gonzalez-Crussi, and J. W. Fowler (1980) J. Pediatr. 96, 47–50.PubMedCrossRefGoogle Scholar
  106. Strobel, R. J., V. M. Riccardi, D. H. Ledbetter, and H. M. Hittner (1980), Am. J. Med. Genet. 7, 15–20.CrossRefGoogle Scholar
  107. van Heyningen, V., W. A. Bickmore, A. Seawright, J. M. Fletcher, J. Maule, G. Fekete, M. Gessler, G. A. P. Bruns, C. Huerre-Jeanpierre, C. Junien, B. R. G. Williams, and H. D. Hastie (1990), Proc. Natl. Acad. Sci. USA 87, 5383–5386.PubMedCrossRefGoogle Scholar
  108. Wadey, R. B., N. Pal, B. Buckle, E. Yeomans, J. Pritchard, and J. K. Cowell (1990), Oncogene 5, 901–907.PubMedGoogle Scholar
  109. Wang, H. P. and C. E. Rogler (1988), Cytogenet. Cell Genet. 48, 72.PubMedCrossRefGoogle Scholar
  110. Weissman, B. E., P. J. Saxon, S. R. Pasquale, G. R. Jones, A. G. Geiser, and E. F. Stanbridge (1987), Science 236, 175–180.PubMedCrossRefGoogle Scholar
  111. Weston, A., J. C. Willey, H. Sugimura, E. M. McDowell, J. Resau, B. Light, A. Haugen, D. L. Mann, B. F. Trump, and C. C. Harris (1989), Proc. Natl. Acad. Sci. USA 86, 5099–5103.PubMedCrossRefGoogle Scholar
  112. Wiedemann, H. R. (1964), J. Genet. Hum. 13, 232, 233.Google Scholar
  113. Wilkins, R. J. (1988), Lancet 1, 329–331.PubMedCrossRefGoogle Scholar
  114. Yoshimoto, K., M. Iizuka, H. Iwahana, R. Yamasaki, H. Saito, S. Saito, and T. Sekiya (1989), Cancer Res. 49, 2716–2721.PubMedGoogle Scholar
  115. Yunis, J. J. and N. K. C. Ramsey (1980), J. Pediatr. 96, 1027–1030.PubMedCrossRefGoogle Scholar
  116. Zhang, Y. and B. Tycko (1992), Nature Genet. 1, 40–44.PubMedCrossRefGoogle Scholar

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