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C-myc as a Tumor Marker for Primary Human Cancers

  • Taro Shuin
Chapter
Part of the Contemporary Biomedicine book series (CB, volume 12)

Abstract

Activated proto-oncogenes play an important role in the development and progression of human cancers. C-myc, one of these protooncogenes, was first identified through its homology to the cancer inducing oncogene present in avian myelocytoma virus MC29 (Duesberg et al., 1977). Molecular studies have revealed that c-myc protein is one of the essential proteins for cellular DNA replication and enhancement of mRNA transcription. Both c-myc messenger RNA and protein have very short half-lives (<30 min) (Dani et al., 1984; Rabbitts et al., 1985; Jones and Cole, 1987). C-myc protein is phosphorylated at serine and threonine, and binds to specific sequences of genomic DNA in a manner analogous to c-fos and c-jun (Ariga et al., 1989; reviewed by Cole, 1986). However, actual functions and regulatory mechanisms of its expression have not been fully clarified. Recently, Max and DMax, two proteins that can form heterodimers with c-myc protein, were discovered (Makela et al., 1992). Studies on these proteins may further clarify the precise actions of c-myc.

Keywords

Human Papilloma Virus Testicular Cancer Cancer Marker SCLC Cell Line Primary Human Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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