DNA Repair and Simple Recombination

  • Edward A. Birge

Abstract

All organisms and some viruses have their own mechanisms for maintaining the integrity of their nucleic acid (i.e., for repairing any damage). Nevertheless, most organisms can undergo some sort of genetic transfer or exchange process(es). The two mechanisms may seem antithetical because recombination, the movement of genetic information from one molecule of nucleic acid to another, implies that a nucleic acid molecule loses its integrity and undergoes some kind of structural alteration. However, as is discussed in this chapter, many of the steps involved in completion of the recombination process are the same as those involved in repair, and recombination can be looked on as a process in which the potential for damage to the genetic information contained in a nucleic acid is outweighed by the potential benefit to be derived from new genetic information or from the ability to repair potentially lethal damage.

Keywords

RecA Protein Pyrimidine Dimer Strand Exchange Strand Invasion LexA Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

General

  1. Adams, R.L.P., Knowler, J.T., Leader, D.P. (1992). The Biochemistry of the Nucleic Acids, eleventh edition. London: Chapman & Hall. (Chapter 7 discusses repair and recombination.)Google Scholar
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Specialized

  1. Lu, C, Scheuermann, R.H., Echols, H. (1986). Capacity of RecA protein to bind preferentially to UV lesions and inhibit the editing subunit (e) of DNA polymerase III: A possible mechanism for SOS-induced targeted mutagenesis. Proceedings of the National Academy of Sciences of the United States of America 83:619–623.PubMedCrossRefGoogle Scholar
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  3. Rajagopalan, M., Lu, C, Woodgate, R. (1992). Activity of the purified mutagenesis proteins UmuC, UmuD’, and RecA in replicative bypass of an abasic DNA lesion by DNA polymerase III. Proceedings of the National Academy of Sciences of the United States of America 89:10777–10781.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Edward A. Birge
    • 1
  1. 1.Department of MicrobiologyArizona State UniversityTempeUSA

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