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Modulation of Ionic Currents by Metabotropic Glutamate Receptors in the CNS

  • Chapter
The Metabotropic Glutamate Receptors

Part of the book series: The Receptors ((REC))

Abstract

Stimulation of neuronal metabotropic glutamate receptors (mGluRs) activates G-proteins initiating a multitude of intracellular processes. Electrophysiological observations indicate that ion channels are among the substrates for the intracellular messengers dispatched by activated mGluRs, thus modulating the electrical behavior of neurons owing to their coupling to numerous membrane ionic conductances. In some of the first experiments to demonstrate metabotropic effects of glutamate, electrophysiological techniques were employed using transfected oocytes to assay for changes in second-messenger levels in response to glutamate (Sugiyama et al., 1987, 1989). It has only recently been shown that activation of mGluRs can also modify the firing properties of neurons (Stratton et al., 1989, 1990; Baskys et al., 1990; Charpak et al., 1990; Desai and Conn, 1991).

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Authors
  1. Urs Gerber
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  2. Beat H. Gähwiler
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Editors and Affiliations

  1. Department of Pharmacology, Emory University, Atlanta, GA, USA

    P. Jeffrey Conn

  2. Zeneca Pharmaceuticals Group, Wilmington, DE, USA

    Jitendra Patel

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Gerber, U., Gähwiler, B.H. (1994). Modulation of Ionic Currents by Metabotropic Glutamate Receptors in the CNS. In: Conn, P.J., Patel, J. (eds) The Metabotropic Glutamate Receptors. The Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2298-7_5

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  • DOI: https://doi.org/10.1007/978-1-4757-2298-7_5

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