Molecular Cloning, Expression, and Characterization of Metabotropic Glutamate Receptor Subtypes

  • Peter D. Suzdak
  • Christian Thomsen
  • Eileen Mulvihill
  • Peter Kristensen
Part of the The Receptors book series (REC)


The excitatory amino acid, l-glutamate, is a primary neurotransmitter in excitatory synaptic pathways in the central nervous system (for a review, see Monaghan et al., 1989; Headley and Grillner, 1990; Mayer and Miller 1990; Nakanishi, 1992). l-Glutamate-mediated neurotransmission is involved in numerous neuronal functions, and excess glutamatergic stimulation may also be involved in the etiology of stroke, epilepsy, and neurodegenerative disorders (Monaghan et al., 1989; Meldrum and Garthwaite, 1990). Receptors for l-glutamate can be classified into two distinct groups based on their signal transduction pathways: (1) ionotropic glutamate receptors, which when activated are directly coupled to the opening of cationic channels (MacDermott et al., 1986; Murphy et al., 1987)—ionotropic glutamate receptors have been further defined by pharmacological and electrophysiological selectivity for N-methyl-d-aspartate (NMDA), α-amino-3-hydroxyl-5-methyl-1-isoxazole-4-propionic acid (AMPA), and kainic acid—and (2) metabotropic glutamate receptors (mGluRs), which are G-protein-coupled receptors (Monaghan et al., 1989; Nahorski and Potter, 1989; Mayer and Miller, 1990; Schoepp and Conn, 1993).


Xenopus Oocyte Excitatory Amino Acid Metabotropic Glutamate Receptor Pertussis Toxin Agonist Selectivity 
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© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Peter D. Suzdak
  • Christian Thomsen
  • Eileen Mulvihill
  • Peter Kristensen

There are no affiliations available

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