The Sarcoplasmic Reticulum Modulates Ca2+- Dependent Vasoconstriction

  • Regent Laporte
  • Ismail Laher
Part of the Experimental Biology and Medicine book series (EBAM, volume 26)


Calcium ions (Ca2+) play a central role in muscle contraction in that they regulate events that result in excitation-contraction coupling. Signaling at the plasma membrane of arteries and veins — either by receptor stimulation or depolarization — leads to a decrease in the approximately 10,000 fold electrochemical gradient for Ca2+, chiefly by increasing the permeability to extracellular Ca2+ and by mobilizing intracellular stores of Ca2+. Voltage changes that accompany production of vascular tone lead to activation of Ca2+ channels (Nelson et al., 1988). Vasoconstrictor agonists cause receptor mediated stimulation of G-proteins, which in turn leads to activation of phospholipase C and the generation of two key intracellular messengers — inositol 1,4,5 trisphosphate (IP3) and diacylglycerol (DAG) (Berridge, 1993). DAG promotes the activation of protein kinase C to a highly Ca2+ -sensitive form leading to phosphorylation of a number of intracellular targets including K+ and Ca2+ ion channels involved in the production of smooth muscle tone (Bonev and Nelson, 1993; Fish et al., 1988).


Smooth Muscle Sarcoplasmic Reticulum Internal Store Smooth Muscle Tone Rabbit Aorta 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Regent Laporte
    • 1
  • Ismail Laher
    • 1
  1. 1.Department of PharmacologyUniversity of VermontBurlingtonUSA

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