Effect of Chronic Ischemia on Human Small Arteries
Critical limb ischemia (CLI) is the term used to describe chronic ischemia which is of a severity to endanger the whole or part of the leg. It is generally caused by advanced atherosclerotic peripheral vascular disease producing an occlusion of a large artery or arteries in the leg. The hemodynamic consequences are increased resistance at the proximal obstruction with a reduction in distal perfusion pressure and blood flow to the peripheral circulation (1).
KeywordsNitric Oxide Small Artery Chronic Ischemia Concentration Response Curve Small Resistance Artery
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