Hypercholesterolaemia and Vascular Function

  • G. K. Goode
  • A. M. Heagerty
Part of the Experimental Biology and Medicine book series (EBAM, volume 26)


Hypercholesterolaemia is a major risk factor for coronary heart disease and is associated with atheroma formation1, which tends to affect large and medium sized arteries especially at sites of turbulent blood flow. An important event in this process is an alteration in the functional or structural properties of the vascular endothelium. Evidence suggests that this endothelial dysfunction is an early event in atherogenesis and may well precede the development of atherosclerosis2,3. Studies in cholesterol-fed animals4–7 and humans with raised serum lipids8–10 have demonstrated abnormalities in vascular function which is usually manifested by an impairment in endothelium-dependent vasorelaxation, although altered smooth muscle sensitivity9 or poteniated vasoconstriction11 have also been suggested. We shall discuss the evidence that raised serum lipids affects arterial function, with particular attention to their effects on small arteries.


Endothelial Dysfunction Rabbit Aorta Calcium Ionophore A23187 Porcine Coronary Artery Arterial Function 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • G. K. Goode
    • 1
  • A. M. Heagerty
    • 1
  1. 1.Department of MedicineUniversity Hospital of South ManchesterManchesterUK

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