Does Intracellular pH Affect Vascular Tone?
It is well established that a reduction of extracellular pH (pHo) is associated with a reduction of tone in most vascular beds. It has though been difficult to assess the importance of intracellular pH (pHi) for this response mainly because it has previously been difficult to measure pHi in vascular smooth muscle and endothelial cells of the vasculature. Over recent years the availability of pH sensitive intracellularly trapped fluorescent dyes have, however, made it possible to address the role of pHi for vascular function and it is the purpose of this short paper to review the literature, which have addressed this question.
KeywordsVascular Tone Force Development Hypercapnic Acidosis Steady State Reduction Subcutaneous Small Artery
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