K(ATP)+ Channels in Neonatal Pulmonary Vessels during Normal Development and Chronic Hypoxia

  • Piet J. Boels
  • Robert M. Tulloh
  • Sheila G. Haworth
Part of the Experimental Biology and Medicine book series (EBAM, volume 26)


The pulmonary circulation undergoes major morphological changes at birth and during adaptation to extra-uterine life (Haworth, 1988, Haworth & Hislop, 1981). It has recently been appreciated that this vascular remodelling is accompanied by major changes in the pharmacological reactivity of the large arteries (Liu et al., 1992). It is unknown to what extent these changes could be caused by alterations of K+-channels, which have emerged as an important mechanism in the control of vascular tone (Nelson et al., 1991, Standen et al. 1989, Weston & Edwards, 1991).


Large Artery Pulmonary Circulation Chronic Hypoxia Newborn Piglet Small Pulmonary Artery 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Piet J. Boels
    • 1
  • Robert M. Tulloh
    • 1
  • Sheila G. Haworth
    • 1
  1. 1.Pharmacology and Vascular Biology UnitInstitute of Child HealthLondonUK

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