Distension Influences Responses to Agonists and Potassium in Several Types of Small Artery

  • Harrie C. M. Boonen
  • Jo G. R. De Mey
Part of the Experimental Biology and Medicine book series (EBAM, volume 26)


Excitation-contraction coupling mechanisms in vascular smooth muscle were classically subdivided into i) electro-mechanical coupling which through depolarisation of the cell membrane opens voltage operated calcium channels and induces contraction through the influx of calcium and ii) pharmaco-mechanical coupling which via receptor activation evokes the influx of calcium, release of calcium from intracellular stores and sensitises the contractile apparatus for calcium (1). Many vascular responses, however, can not solely be explained by either of these mechanisms. Examples of these include the myogenic response to pressure increases (2), flow and stretch induced responses (3, 4) and on a longer term basis effects of flow and pressure on vascular structure (5). What these responses have in common is that they are initiated by a mechanical stimulus. A perturbation of the strain and stress is sensed, transduced and translated into a cellular response. The mechanisms by which this is achieved are still subject of intense research.


Vascular Smooth Muscle Small Artery Vascular Reactivity Myogenic Response Isotonic Condition 
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  1. 1.
    SOMLYO, A. V., AND A. P. SOMLYO. Electromechanical and pharmacomechanical coupling in vascular smooth muscle. J. Pharmacol. Exp. Therap. 159: 129–145, 1968.Google Scholar
  2. 2.
    JOHNSON, P. C. The myogenic response. In: Handbook of Physiology: The cardiovascular system Vascular smooth muscle. Bethesda, MD: Am Physiol. Soc., Vol. II, 1980, p. 409–442.Google Scholar
  3. 3.
    BEVAN, J. A., AND E. H. JOYCE. Calcium dependence of flow-induced dilation. Cooperative interaction with sodium. Hypertension. 21: 16–21, 1993.PubMedCrossRefGoogle Scholar
  4. 4.
    LAHER, I., AND J. A. BEVAN. Stretch of vascular smooth muscle activates tone and Ca’ influx. J. Hypertension. 7: S17- S20, 1989.Google Scholar
  5. 5.
    LANGILLE, B. L., M. P. BENDECK, AND F. W. KEELEY. Adaptations of carotid arteries of young and mature rabbits to reduced carotid blood flow. Am. J. Physiol. 256: H931 - H939, 1989.PubMedGoogle Scholar
  6. 6.
    BOONEN, H. C. M., AND J. G. R. DE MEY. Increased calcium sensitivity in isolated resistance arteries from spontaneously hypertensive rats: effects of dihydropyridines. Eur. J. Pharmacol. 179: 403–412, 1990.PubMedCrossRefGoogle Scholar
  7. 7.
    DE MEY, J. G. R., AND D. L. BRUTSAERT. Mechanical properties of resting and active isolated coronary arteries. Circ. Res. 55: 1–9, 1984.PubMedCrossRefGoogle Scholar
  8. 8.
    MURPHY, R. A. Mechanics of vascular smooth muscle. In: Handbook of physiology. The cardiovascular system, Am. Physiol. Soc. Bethesda, MD:, Vol. II, 1980, p. 325–351.Google Scholar
  9. 9.
    GORDON, A. M., A. F. HUXLEY, AND F. J. JULIAN. The variation in isometric tension with sarcomere length in vertebrate muscle fibers. J. Physiol. 184: 170–192, 1966.PubMedGoogle Scholar
  10. 10.
    ROMAN, R. J., AND D. R. HARDER. Cellular and ionic signal transduction mechanisms for the mechanical activation of renal arterial vascular smooth muscle. J. Am. Soc. Nephrol. 4: 986–996, 1993.PubMedGoogle Scholar
  11. 11.
    SMEDA, J. S., AND E. E. DANIEL Elevations in arterial pressure induce the formation of spontaneous action potentials and alter neurotransmission in canine ileum arteries. Circ. Res. 62: 1104–1110, 1988.PubMedCrossRefGoogle Scholar
  12. 12.
    HILL, M. A., J. C. FALCONE, AND G. A. MEININGER. Evidence for protein kinase-C involvement in arteriolar reactivity. Am. J. Physiol. 259: H1586 - H1594, 1990.PubMedGoogle Scholar
  13. 13.
    OSOL, G., I. LAHER, AND M. KELLEY. Myogenic tone is coupled to phospholipase C and G protein activation in small cerebral arteries. Am. J. Physiol. 265: H415 - H420, 1993.PubMedGoogle Scholar
  14. 14.
    DAVIS, M. J., J. A. DONOVITZ, AND J. D. HOOD. Stretch-activated single-channel and whole cell currents in vascular smooth muscle cells. Am. J. Physiol. 262: C1083 - C1088, 1992.PubMedGoogle Scholar
  15. 15.
    MULVANY, M. J., AND D. M. WARSHAW. The active tension-length curve of vascular smooth muscle related to its cellular components. J. Gen. Physiol. 74: 85–104, 1979.PubMedCrossRefGoogle Scholar
  16. 16.
    NILSSON, H., AND N. SJÖBLOM. Distension-dependent changes in noradrenaline sensitivity in small arteries from the rat. Acta. Physiol. Scand. 125: 429–435, 1985.PubMedCrossRefGoogle Scholar
  17. 17.
    PRICE, J. M., D. L. DAVIS, AND E. B. KNAUSS. Length-dependent sensitivity in vascular smooth muscle. Am. J. Physiol. 241: H557 - H563, 1981.PubMedGoogle Scholar
  18. 18.
    DALY, C. J., J. F. GORDON, AND J. C. MCGRATH. The use of fluorescent dyes for the study of blood vessel structure and function: Novel applications of existing techniques. J. Vasc. Res 29: 41–48, 1992.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Harrie C. M. Boonen
    • 1
  • Jo G. R. De Mey
    • 1
  1. 1.Department of Pharmacology and Cardiovascular Research Institute Maastricht (CARIM)University of LimburgMaastrichtthe Netherlands

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