Exercise Training Augments EDRF (Nitric Oxide) Synthesis in Skeletal Muscle Arterioles

  • Akos Koller
  • Dong Sun
  • An Huang
  • Gabor Kaley
Part of the Experimental Biology and Medicine book series (EBAM, volume 26)


Recent in vivo (5,7,18) and in vitro (21,22) studies provide ample evidence for the participation of EDRF (nitric oxide) in the mediation of the action of various vasoactive substances and in the basal regulation of microvascular tone. Despite these findings however, there are only few, if any, studies suggesting a role for EDRF/NO in the various autoregulatory responses of microvessels in skeletal muscle. For example, previously we found that in rat cremasteric arterioles reactive hyperemia and flow dependent dilation are mediated by another endothelium-derived agent, namely prostaglandin(s), rather than nitric oxide (8,9,10). A contribution of prostaglandins in exercise-induced vasodilation was also reported in human forearm experiments (24). No definitive role for EDRF, however, was found in the development of functional hyperemia in the cat hind limb (19), whereas in dogs a role for EDRF was shown in phrenic nerve stimulation-induced hyperemia in the diaphragm (6) and in skeletal muscle hyperemia to acute exercise (21).


Nitric Oxide Wall Shear Stress Perfusate Flow Gracilis Muscle Endothelium Dependent Dilation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bevan, J.A. and E.H. Joyce. Saline infusion into lumen of resistance artery and small vein causes contraction. Am. J. Physiol. 259 (Heart Circ. Physiol. 28):H23–H28, 1990.Google Scholar
  2. 2.
    Bjömbeig, J., U. Albert and S. Mellander. Resistance responses in proximal arterial vessels, arterioles and veins during reactive hyperaemia in skeletal muscle and their underlying regulatory mechanisms. Acta Physiol. Scan. 139:535–550, 1990.CrossRefGoogle Scholar
  3. 3.
    Bloomqvist, C.G. and B. Saltin. Cardiovascular adaptations to physical training. Anni,. Rev. Physiol. 45:988–992, 1983.Google Scholar
  4. 4.
    Delp, M.D., RM. McAllister and M.H. Laughlin. Exercise training alters endothelium-dependent vasoreactivity of rat abdominal aorta. J. Appl. Physiol. 75(3):1354–1363, 1993.PubMedGoogle Scholar
  5. 5.
    Ekelund, U. and S. Mellander. Role of endothelium-derived nitric oxide in the regulation of tonus in large-bore arterial resistance vessels, arterioles and veins in cat skeletal muscles. Acta Physiol. Scand. 140:301–309, 1990.Google Scholar
  6. 6.
    Hussain, S.N.A., D.J. Stewart, J.P. Ludemann and S. Magder. Role of endothelium-derived relaxing factor in active hyperemia of the canine diaphragm. J Appl. Physiol. 72(6):2393–2401, 1992.Google Scholar
  7. 7.
    Kaley, G., A. Koller, J.M. Rodenbuig, E.J. Messina and M.S. Wolin. Regulation of arteriolar tone and responses via L-arginine pathway in skeletal muscle. Am. J. Physiol. 262 (Heart Circ. Physiol. 31):H987–H992, 1992.Google Scholar
  8. 8.
    Koller, A. and G. Kaley. Prostaglandins mediate arteriolar dilation to increase blood flow velocity in skeletal muscle microcirculation. Circ. Res. 67:529–534, 1990.Google Scholar
  9. 9.
    Koller, A. and G. Kaley. Endothelial regulation of wall shear stress and blood flow in skeletal muscle microcirculation. Am. J. Physiol. 260(Heart and Circ. Physiol. 29):H862–H868, 1991.Google Scholar
  10. 10.
    Koller A., D. Sun and G. Kaley. Role of shear stress and endothelial prostaglandins in flow and viscosity-induced dilation of arterioles in vitro. Circ. Res. 72:1276–1284, 1993.Google Scholar
  11. 11.
    Koller, A., D. Sun, and A. Huang and G. Kaley. Corelease of nitric oxide and prostaglandins to flow dilates rat gracilis muscle arterioles. Am. J. Physiol. (in press), 1994.Google Scholar
  12. 12.
    Kuo, L., W.M. Chilian and M.J. Davis. Interaction of pressure and flow -induced responses in porcine coronary resistance vessels. Am. J. Physiol. 261 (Heart Circ. Physiol. 30):H1706–H1715, 1991.Google Scholar
  13. 13.
    Lamontagne, D., U. Pohl and R Busse. Mechanical deformation of vessel wall and shear stress determine the basal EDRF release in the intact coronary vascular bed. Circ. Res. 70:123–130, 1992.Google Scholar
  14. 14.
    Lash, J.M. and H.G. Bohlen. Functional adaptations of rat skeletal muscle arterioles to aerobic exercise training. J. Appl. Physiol. 72(6):2052–2062, 1992.Google Scholar
  15. 15.
    Laughlin, M.H. and RB. Armstrong. Muscular blood flow distribution patterns as a functional of running speed in rats. Am. J. Phsiol. 243 (Heart Circ. Physiol. 12):H296–H306, 1982.PubMedCrossRefGoogle Scholar
  16. 16.
    Melkumyants, A.M., S.A. Balashov, A.N. Klimachev, S.P. Kartamyshev and V.M. Khayutin. Nitric oxide does not mediate flow induced endothelium dependent arterial dilation in the cat. Cardiovasc. Res. 26:256–260, 1992.PubMedCrossRefGoogle Scholar
  17. 17.
    Miller, V.M. and P.M. Vanhoutte. Enhanced release of endothelium-derived relaxing factor by chronic increased in blood flow. Am. J. Physiol. 255 (Heart Circ. Physiol.) H446–H451, 1988.Google Scholar
  18. 18.
    Nakamura, T. and RL. Prewitt. Effect of NG- monomethyl-L-arginine on arcade arterioles of rat spinotrapezius muscles. Am. J. Physiol. 261 (Heart Circ. Physiol. 30):H46–H52, 1991.Google Scholar
  19. 19.
    Persson, M.G., N.P. Wiklund, P. Hedqvist and L.E. Gustafsson. Microvascular effects of local or systemic inhibition of endogenous endothelium-derived relaxing factor (nitric oxide) production. J. of Cardiovascular Pharmacology 17(Suppl. 3):S169–S172, 1991.CrossRefGoogle Scholar
  20. 20.
    Sessa, W.C., K. Pritchard, N. Seyedi, J. Wang, and T.H. Hintze. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ. Res. 74:349–353, 1994.CrossRefGoogle Scholar
  21. 21.
    Shen, W., M. Lundborg, J. Want, J.M. Stewart, X. Xu, M. Ochoa and T.H. Hintz. Role of EDRF in the regulation of regional blood flow and vascular resistance at rest and during exercise in conscious dogs. J. of Applied Physiol. (in press).Google Scholar
  22. 22.
    Sun, D., E.J., Messina, A. Koller, M.S. Wolin and G. Kaley. Endothelium dependent dilation to L-arginine in isolated rat skeletal muscle arterioles. Am. J. Physiol. 262 (Heart circ. Physiol. 32):H1486–H1791, 1992.Google Scholar
  23. 23.
    Sun, D., G. Kaley and A. Koller. characteristics and origins of the myogenic response is isolated gracilis muscle arterioles. Am. J. Physiol. (Heart Circ. Physiol.) (in press), 1993.Google Scholar
  24. 24.
    Sun, D., A. Huang, A. Koller and G. Kaley. Short term daily exercise activity enhances endothelial nitric oxide synthesis in skeletal muscle arterioles of rats. J. of Appl. Physiol. (in press), 1994.Google Scholar
  25. 25.
    Wilson, J.R. and S.C. Kapoor. Contribution of prostaglandins to exercise-induced vasodilation in humans. Am. J Physiol. 265 (Heart Circ. Physiol. 34):H171–H175, 1993.Google Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Akos Koller
    • 1
  • Dong Sun
    • 1
  • An Huang
    • 1
  • Gabor Kaley
    • 1
  1. 1.New York Medical CollegeValhallaUSA

Personalised recommendations