Abstract
Recent in vivo (5,7,18) and in vitro (21,22) studies provide ample evidence for the participation of EDRF (nitric oxide) in the mediation of the action of various vasoactive substances and in the basal regulation of microvascular tone. Despite these findings however, there are only few, if any, studies suggesting a role for EDRF/NO in the various autoregulatory responses of microvessels in skeletal muscle. For example, previously we found that in rat cremasteric arterioles reactive hyperemia and flow dependent dilation are mediated by another endothelium-derived agent, namely prostaglandin(s), rather than nitric oxide (8,9,10). A contribution of prostaglandins in exercise-induced vasodilation was also reported in human forearm experiments (24). No definitive role for EDRF, however, was found in the development of functional hyperemia in the cat hind limb (19), whereas in dogs a role for EDRF was shown in phrenic nerve stimulation-induced hyperemia in the diaphragm (6) and in skeletal muscle hyperemia to acute exercise (21).
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References
Bevan, J.A. and E.H. Joyce. Saline infusion into lumen of resistance artery and small vein causes contraction. Am. J. Physiol. 259 (Heart Circ. Physiol. 28):H23–H28, 1990.
Bjömbeig, J., U. Albert and S. Mellander. Resistance responses in proximal arterial vessels, arterioles and veins during reactive hyperaemia in skeletal muscle and their underlying regulatory mechanisms. Acta Physiol. Scan. 139:535–550, 1990.
Bloomqvist, C.G. and B. Saltin. Cardiovascular adaptations to physical training. Anni,. Rev. Physiol. 45:988–992, 1983.
Delp, M.D., RM. McAllister and M.H. Laughlin. Exercise training alters endothelium-dependent vasoreactivity of rat abdominal aorta. J. Appl. Physiol. 75(3):1354–1363, 1993.
Ekelund, U. and S. Mellander. Role of endothelium-derived nitric oxide in the regulation of tonus in large-bore arterial resistance vessels, arterioles and veins in cat skeletal muscles. Acta Physiol. Scand. 140:301–309, 1990.
Hussain, S.N.A., D.J. Stewart, J.P. Ludemann and S. Magder. Role of endothelium-derived relaxing factor in active hyperemia of the canine diaphragm. J Appl. Physiol. 72(6):2393–2401, 1992.
Kaley, G., A. Koller, J.M. Rodenbuig, E.J. Messina and M.S. Wolin. Regulation of arteriolar tone and responses via L-arginine pathway in skeletal muscle. Am. J. Physiol. 262 (Heart Circ. Physiol. 31):H987–H992, 1992.
Koller, A. and G. Kaley. Prostaglandins mediate arteriolar dilation to increase blood flow velocity in skeletal muscle microcirculation. Circ. Res. 67:529–534, 1990.
Koller, A. and G. Kaley. Endothelial regulation of wall shear stress and blood flow in skeletal muscle microcirculation. Am. J. Physiol. 260(Heart and Circ. Physiol. 29):H862–H868, 1991.
Koller A., D. Sun and G. Kaley. Role of shear stress and endothelial prostaglandins in flow and viscosity-induced dilation of arterioles in vitro. Circ. Res. 72:1276–1284, 1993.
Koller, A., D. Sun, and A. Huang and G. Kaley. Corelease of nitric oxide and prostaglandins to flow dilates rat gracilis muscle arterioles. Am. J. Physiol. (in press), 1994.
Kuo, L., W.M. Chilian and M.J. Davis. Interaction of pressure and flow -induced responses in porcine coronary resistance vessels. Am. J. Physiol. 261 (Heart Circ. Physiol. 30):H1706–H1715, 1991.
Lamontagne, D., U. Pohl and R Busse. Mechanical deformation of vessel wall and shear stress determine the basal EDRF release in the intact coronary vascular bed. Circ. Res. 70:123–130, 1992.
Lash, J.M. and H.G. Bohlen. Functional adaptations of rat skeletal muscle arterioles to aerobic exercise training. J. Appl. Physiol. 72(6):2052–2062, 1992.
Laughlin, M.H. and RB. Armstrong. Muscular blood flow distribution patterns as a functional of running speed in rats. Am. J. Phsiol. 243 (Heart Circ. Physiol. 12):H296–H306, 1982.
Melkumyants, A.M., S.A. Balashov, A.N. Klimachev, S.P. Kartamyshev and V.M. Khayutin. Nitric oxide does not mediate flow induced endothelium dependent arterial dilation in the cat. Cardiovasc. Res. 26:256–260, 1992.
Miller, V.M. and P.M. Vanhoutte. Enhanced release of endothelium-derived relaxing factor by chronic increased in blood flow. Am. J. Physiol. 255 (Heart Circ. Physiol.) H446–H451, 1988.
Nakamura, T. and RL. Prewitt. Effect of NG- monomethyl-L-arginine on arcade arterioles of rat spinotrapezius muscles. Am. J. Physiol. 261 (Heart Circ. Physiol. 30):H46–H52, 1991.
Persson, M.G., N.P. Wiklund, P. Hedqvist and L.E. Gustafsson. Microvascular effects of local or systemic inhibition of endogenous endothelium-derived relaxing factor (nitric oxide) production. J. of Cardiovascular Pharmacology 17(Suppl. 3):S169–S172, 1991.
Sessa, W.C., K. Pritchard, N. Seyedi, J. Wang, and T.H. Hintze. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ. Res. 74:349–353, 1994.
Shen, W., M. Lundborg, J. Want, J.M. Stewart, X. Xu, M. Ochoa and T.H. Hintz. Role of EDRF in the regulation of regional blood flow and vascular resistance at rest and during exercise in conscious dogs. J. of Applied Physiol. (in press).
Sun, D., E.J., Messina, A. Koller, M.S. Wolin and G. Kaley. Endothelium dependent dilation to L-arginine in isolated rat skeletal muscle arterioles. Am. J. Physiol. 262 (Heart circ. Physiol. 32):H1486–H1791, 1992.
Sun, D., G. Kaley and A. Koller. characteristics and origins of the myogenic response is isolated gracilis muscle arterioles. Am. J. Physiol. (Heart Circ. Physiol.) (in press), 1993.
Sun, D., A. Huang, A. Koller and G. Kaley. Short term daily exercise activity enhances endothelial nitric oxide synthesis in skeletal muscle arterioles of rats. J. of Appl. Physiol. (in press), 1994.
Wilson, J.R. and S.C. Kapoor. Contribution of prostaglandins to exercise-induced vasodilation in humans. Am. J Physiol. 265 (Heart Circ. Physiol. 34):H171–H175, 1993.
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Koller, A., Sun, D., Huang, A., Kaley, G. (1994). Exercise Training Augments EDRF (Nitric Oxide) Synthesis in Skeletal Muscle Arterioles. In: Halpern, W., Bevan, J., Brayden, J., Dustan, H., Nelson, M., Osol, G. (eds) The Resistance Arteries. Experimental Biology and Medicine, vol 26. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2296-3_15
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