Protein Kinase C (PKC) Activation Lowers the Calcium Requirement for Cerebral Artery Myogenic Tone

  • George Osol
Part of the Experimental Biology and Medicine book series (EBAM, volume 26)


The occurrence of myogenic tone in the cerebral circulation is well documented, and a number of earlier studies have characterized both the extent and pattern of arterial responses to altered transmural pressure (1–4). With the possible exception of the cat (4,5), the response of cerebral arteries to pressure or stretch appears to be truly myogenic in nature in most species examined (see 6 for review), although there are still several large gaps in our understanding of the underlying mechanisms. For example, neither the identity nor the location of the mechanosensor sensor is known, and the intracellular transduction mechanisms are only now beginning to be understood. Currently, the consensus is that the expression of myogenic tone involves a complementary interaction between transmembrane ionic fluxes and enzymatic activation.


Cerebral Artery Physiological Saline Solution Calcium Entry Lumen Diameter Transmural Pressure 
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  1. 1.
    Vinall, P.E. and F.A. Simeone. Cerebral autoregulation: an in vitro study. Stroke 12: 640–642, 1981.PubMedCrossRefGoogle Scholar
  2. 2.
    Osol, G. and W. Halpern. Myogenic properties of cerebral vessels from normotensive and hypertensive rats. Am. J. Physiol. 249: H914 - H921, 1985.Google Scholar
  3. 3.
    Osol, G., R. Osol, and W. Halpern. Effects of diltiazem on myogenic tone in pressurized brain arteries from spontaneously hypertensive rats, In: Essential Hypertension: Calcium mechanisms and treatment, Aoki, K (Ed), Springer-Verlag, Tokyo, pp. 107–113, 1986.Google Scholar
  4. 4.
    Harder, D.R. Pressure-induced myogenic activation of cat cerebral arteries is dependent on an intact endothelium. Circ. Res. 60: 102–107, 1987.Google Scholar
  5. 5.
    Brayden, J.E. and G.C. Wellman. Endothelium-dependent dilation of feline cerebral arteries: role of membrane potential and cyclic nucleotides. J. Cereb. Blood Flow 9: 256–263, 1989.CrossRefGoogle Scholar
  6. 6.
    Meininger, G.A. and M.J. Davis. Cellular mechanisms involved in the vascular myogenic response. Am. J. Physiol. 263; H647 - H659, 1992.Google Scholar
  7. 7.
    Meininger, G.A., D.C. Zawieja, J.C. Falcone, M.A. Hill, and J.P. Davey. Calcium measurement in isolated arterioles during myogenic and agonist stimulation. Am. J. Physiol. 261: H647 - H659, 1991.Google Scholar
  8. 8.
    Bevan, J.A. and Laher, I. Pressure and flow-dependent vascular tone. FASEB J. 5: 2267–2273, 1991.PubMedGoogle Scholar
  9. 9.
    Harder, D.R. Pressure-dependent membrane depolarization in cat middle cerebral artery. Circ. Res. 55: 197–202, 1984.PubMedCrossRefGoogle Scholar
  10. 10.
    Nelson, M.T., N.B. Standen, J.E. Brayden, and J.F. Worley. Noradrenaline contracts arteries by activating voltage-dependent calcium channels. Nature 336: 382–385, 1988.PubMedCrossRefGoogle Scholar
  11. 11.
    Osol, G., I. Laher and M. Cipolla. Protein kinase C modulates basal myogenic tone in resistance arteries from the cerebral circulation. Circ. Res. 68: 359–367, 1991.PubMedCrossRefGoogle Scholar
  12. 12.
    Osol, G., I. Laher, and M. Kelley. Myogenic tone is coupled to phospholipase C and G protein activation in small cerebral arteries. Am. J. Physiol. 265: H415 - H420, 1993.PubMedGoogle Scholar
  13. 13.
    Hill, M.A., J.C. Falcone, and G.A. Meininger. Evidence for protein kinase C involvement in arteriolar myogenic reactivity. Am. J. Physiol. 259: H1586 - H1591, 1990.Google Scholar
  14. 14.
    Rosales, O.R. and B.E. Sumpio. Protein kinase C is a mediator of the adaptation of vascular endothelial cells to cyclic strain in vitro. Surgery St. Louis 112: 459–466, 1992.Google Scholar
  15. 15.
    Rosales, O.R. and B.E. Sumpio. Changes in cyclic strain frequency increase inositol triphosphate and diacylglycerol in endothelial cells. Am. J. Physiol. 262: C956 - C962, 1992.Google Scholar
  16. 16.
    Deckmyn, H., C. Van Geet, and J. Vermylen. Dual regulation of phospholipase C activity by G proteins. News Physiol. Sci. 8: 61–63, 1993.Google Scholar
  17. 17.
    Halpern, W., G. Osol and G. Coy. Mechanical behavior of pressurized in vitro prearteriolar vessels determined with a video system. Ann. Biomed. Eng. 12: 463–479, 1984.Google Scholar
  18. 18.
    Morgan, J.P. and K.G. Morgan. Stimulus-specific patterns of intracellular calcium levels in smooth muscle of ferret portal vein. J. Physiol. 351: 155–167, 1984.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • George Osol
    • 1
  1. 1.University of Vermont College of MedicineBurlingtonUSA

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