Laserspectroscopy: Technology and Theoretical Background

  • S. Schmidt
  • U. Wagner
  • S. Spaniol
  • N. Helledie
  • P. Rolfe
  • D. Krebs

Abstract

The non-invasive determination of biochemical parameters has become an important aspect of intensive care medicine(2). The newly developed monitors for laser spectroscopy (synonima: nirscopy, reflectometry, reflectance spectrophotometry) provide the possibility of spectroscopic monitoring. The principle was first described by Jobsis who reported on the non-invasive measurement of cerebral and myocardial oxygen sufficiency and circulatory parameters by the means of near-infared spectroscopy(1). The introduction of laser-diodes and the development of mathematical procedures as proposed by Peter Rolfe led to configurations of measuring systems that can be used during research routine(3). Such prototypes has been applied in the field of neonatal intensive care, neurosurgery, and foetal surveillance(4). The configuration of the measuring system aims at the calculation of both the intracellular redox-state and relative changes of blood volume.

Keywords

Laser Spectroscopy Intensive Care Medicine Sodium Dithionite Circulatory Parameter Apparent Absorbance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Cady, E.B., Dawson M.J., Hope P.L.: (1983) Non-invasive investigation of cerebral metabolism in newborn infants by phosphorus nuclear magnetic resonance spectroscopy, Lancet 14 May, 1059–1062Google Scholar
  2. 2.
    Jobsis, F.F.: (1979) Oxidative metabolic effects of cerebral hypoxia. Advances in Neurology, 26, 299–318PubMedGoogle Scholar
  3. 3.
    Rea P.A., Crowe J., Wickramasinghe Y., Rolfe P.: (1985) Noninvasive optical methods for the study of cerebral metabolism in the human newborn: a technique for the future? J. Med. Engl. Technol. 9, 160–166Google Scholar
  4. 4.
    Schmidt S., Lenz A., Eilers H., Helledie N., Krebs D.: (1989) Laser spectrophotometry in the fetus. J. Perinatal. Med. 17, 57–62Google Scholar
  5. 5.
    Stryer L.: Oxidative Phosphorylation. in Biochemistry, Freeman New York 1981Google Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • S. Schmidt
    • 1
    • 2
  • U. Wagner
    • 1
    • 2
  • S. Spaniol
    • 1
    • 2
  • N. Helledie
    • 1
    • 2
  • P. Rolfe
    • 1
    • 2
  • D. Krebs
    • 1
    • 2
  1. 1.Women’s HospitalUniversity of BonnGermany
  2. 2.Dept. of Biomedical Engineering and Medical PhysicsUniversity of KeeleEngland

Personalised recommendations