Laserspectroscopy: Technology and Theoretical Background
The non-invasive determination of biochemical parameters has become an important aspect of intensive care medicine(2). The newly developed monitors for laser spectroscopy (synonima: nirscopy, reflectometry, reflectance spectrophotometry) provide the possibility of spectroscopic monitoring. The principle was first described by Jobsis who reported on the non-invasive measurement of cerebral and myocardial oxygen sufficiency and circulatory parameters by the means of near-infared spectroscopy(1). The introduction of laser-diodes and the development of mathematical procedures as proposed by Peter Rolfe led to configurations of measuring systems that can be used during research routine(3). Such prototypes has been applied in the field of neonatal intensive care, neurosurgery, and foetal surveillance(4). The configuration of the measuring system aims at the calculation of both the intracellular redox-state and relative changes of blood volume.
KeywordsLaser Spectroscopy Intensive Care Medicine Sodium Dithionite Circulatory Parameter Apparent Absorbance
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