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Characterization of the Sulfonylurea-Sensitive ATP-Modulated Potassium Channel

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Methods in Pharmacology

Abstract

ATP-sensitive K+ channels constitute a new class of K+ channels that link membrane potential variations to the bioenergetic situation of the cell (Noma, 1983). K+ channels of this class (KATP channels) are regulated by variations of the internal ATP concentration. At high ATP concentrations the channel is closed. When the concentration of ATP becomes lower the channel opens. Therefore, a low ATP concentration will tend to give a hyperpolarization, whereas higher ATP concentrations will tend to lead to the closing of the KATP channel and produce a depolarization (Ashcroft et al., 1984; Rorsman and Trube, 1985).

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Authors and Affiliations

  1. Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, Sophia Antipolis, Valbonne, France

    Henri Bernardi & Michel Lazdunski

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  1. Henri Bernardi
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  2. Michel Lazdunski
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Editors and Affiliations

  1. Universität Innsbruck, Innsbruck, Austria

    Hartmut Glossmann  & Jörg Striessnig  & 

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© 1993 Springer Science+Business Media New York

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Bernardi, H., Lazdunski, M. (1993). Characterization of the Sulfonylurea-Sensitive ATP-Modulated Potassium Channel. In: Glossmann, H., Striessnig, J. (eds) Methods in Pharmacology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2239-0_3

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  • DOI: https://doi.org/10.1007/978-1-4757-2239-0_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-3232-7

  • Online ISBN: 978-1-4757-2239-0

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