Discussion in detail of the mechanisms involved in long-term memory (LTM) formation at the level of single neurons. Similarities between sensitization and long-term potentiation (LTP). Evidence that LTP is presynaptic. Critique of Alkon’s “dendritic compartment” model of postsynaptic learning. Possibility of positive feedback at the synapse during learning. Intracellular dendritic transfer of protein kinase C (PKC); its possible relation to glutamate receptor types, LTP, and Hebbian convergence effects.
KeywordsVentral Tegmental Area Locus Coeruleus Basal Forebrain Fundamental Mechanism Dendritic Compartment
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