Abstract
Bacteria of the genus Leptospira are ubiquitous, associated with most mammals, and with marsupials and certain amphibia, or found free-living in soil and surface waters. Some strains of leptospires can cause an acute generalized infection, characterized by fever and hemorrhages, called leptospirosis. Leptospires may remain and grow in the kidneys of animals that recover from the acute infection but remain renal excretors or carriers, shedding leptospires in their urine. Humans may be infected but do not remain carriers and are thus not natural hosts.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literature Cited
Adler, B., S. A. Ballard, S. J. Miller, and S. Faine. 1989. Monoclonal antibodies reacting with serogroup and serovar specific epitopes on different lipopolysaccharide subunits of Leptospira interrogans serovar pomona. FEMS Microbiol. Immunol. 47:213–218.
Adler, B., S. Faine, W. L. Christopher, and R. J. Chappel. 1986. Development of an improved selective medium for isolation of leptospires from clinical material. Vet. Microbiol. 12:377–381.
Alexander, A. D. 1985. Leptospira, p. 473–478. In: E. H. Lennette, A. Balows, W. J. Hausler, and H. J. Shadomy (ed.), Manual of clinical microbiology, 4th ed. American Society for Microbiology, Washington.
Alexander, A. D., E. F. Lessel, L. B. Evans, E. Frank, and S. S. Green. 1972. Preservation of leptospiras by liquid-nitrogen refrigeration. Int. J. Syst. Bacteriol. 22:165–169.
Alexander, A. D., and P. Rule. 1986. Penicillins, cephalosporins, and tetracyclines in treatment of hamsters with fatal leptospirosis. Antimicrob. Agents. Chemother. 30:835–839.
Auran, N. E., R. C. Johnson, and D. M. Ritzi. 1972. Isolation of the outer sheath of Leptospira and its immunogenic properties in hamsters. Infect. Immun. 5:968–975.
Baker-Zander, S. A., and S. A. Lukehart. 1984. Antigenic cross-reactivity between Treponema pallidum and other pathogenic members of the family Spirochaetaceae. Infect. Immun. 46:116–121.
Ballard, S. A., B. Adler, D. B. Millar, R. J. Chappel, R. T. Jones, and S. Faine. 1984. The immunoglobulin response of swine following experimental infection with Leptospira interrogans serovar pomona. Zentralbl. Bakteriol. Hyg. A. 256:510–517.
Ballard, S. A., M. Williamson, B. Adler, T. Vinh, and S. Faine. 1986. Interactions of virulent and avirulent leptospires with primary cultures of renal epithelial cells. J. Med. Microbiol. 21:59–67.
Bey, R. F., and R. C. Johnson. 1978. Protein-free and low-protein media for the cultivation of Leptospira. Infect. Immun. 19:562–569.
Broughton, E. S., and L. E. Flack. 1986. The susceptibility of a strain of Leptospira interrogans serogroup icterohaemorrhagiae to amoxycillin, erythromycin, lincomycin, tetracycline, oxytetracycline and minocycline. Zentralbl. Bakteriol. Hyg. A. 261:425–431.
Chang, A., and S. Faine. 1974. Association between the “incomplete serotypes” and the cryptic axial filament antigen of Leptospira. Austral. J. Exp. Biol Med. Sci. 52:569–575.
Cinco, M., M. Tamaro, and L. Cociancich. 1975. Taxonomical, cultural and metabolic characteristics of halophilic leptospirae. Zentralbl. Bakteriol. Hyg. I. Abt. Orig. A. 233:400–405.
Dain, A. A., M. N. Rozinov, and Y. G. Chernukha. 1988. Cloning and expression of a L. pomona hemolysin in E. coli, p. 7.7 In: Proceedings Zoonoses Congress, Brno, Czechoslovakia. Association of Czechoslovak Medical Societies, J. E. Purkinye, Czechoslovak Society for Microbiology and Epidemiology, University of Veterinary Science, Brno, and Faculty of Medicine, Brno.
del Real, G., R. P. A. M. Segers, B. M. van der Zeist, and W. Gaastra. 1989. Cloning of a hemolysin gene from Leptospira interrogans serovar hardjo. Infect. Immun. 57:2588–2590.
Dikken, H., and E. Kmety. 1978. Serological typing methods of leptospires, p.260–295. In: T. Bergan and J. R. Norris (ed.), Methods in microbiology, vol. 11. Academic Press, London.
Doherty, J. P., B. Adler, J. I. Rood, S. J. Billington, and S. Faine. 1989. Expression of two conserved leptospiral antigens in Escherichia coli. J. Med. Microbiol. 28:143–149.
Elder, J. K., G. M. McKeon, E Duncalfe, W. H. Ward, and R. D. Leutton. 1986. Epidemiological studies on the ecology of Leptospira interrogans serovars pomona and hardjo in Queensland. Prey. Vet. Med. 3:501–521.
Ellis, W. A., S. D. Neill, J. J. O’Brien, J. A. Cassells, and J. Hanna. 1982. Bovine leptospirosis: Microbiological and serological findings in normal fetuses removed from the uteri after slaughter. Vet. Rec. 110:192–194.
Faine, S. 1957. Virulence in leptospira. II. The growth in vivo of virulent Leptospira icterohaemorrhagiae. Brit. J. Exp. Pathol. 38:8–14.
Faine, S. 1962. The growth of Leptospira australis B in the kidneys of mice in the incipient experimental camer state. J. Hyg. 60:435–442.
Faine, S. (ed.) 1982. Guidelines for the control of leptospirosis. WHO Offset Publication No. 67. World Health Organization, Geneva.
Faine, S. 1988. Leptospirosis, p. 344–352. In: A. Balows, W. J. Hausler, and E. H. Lennette (ed.), Laboratory diagnosis of infectious diseases. Principles and practice, vol. 1: Bacterial, mycotic, and parasitic diseases. Springer-Verlag, New York.
Faine, S. 1990. Leptospirosis. In: A. E. Evans arid P. S. Brachman (ed.), Bacterial infections of humans, 2nd ed. Plenum, New York. (in press)
Faine, S., B. Adler, and A. Palit. 1974. Chemical, serological and biological properties of a serotype-specific polysaccharide antigen in Leptospira. Austral. J. Exp. Biol. Med. Sci. 52:311–319.
Faine, S., and J. N. Carter. 1968. Natural antibody in mammalian serum reacting with an antigen in some leptospires. J. Bacteriol. 95:280–285.
Faine, S. and W. J. Kaipainen. 1955. Erythromycin in ex- perimental leptospirosis. J. Infect. Dis. 97:146–151.
Faine, S., A. Shahar, and M. Aronson. 1964. Phagocytosis and its significance in leptospiral infection. Austral. J. Exp. Biol. Med. Sci. 42:579–588.
Faine, S., and N. D. Stallman. 1982. Amended descriptions of the genus Leptospira Noguchi 1917 and the species L. interrogans (Stimson 1907) Wenyon 1926 and L. biflexa (Wolbach and Binger 1914) Noguchi 1918. Int. J. Syst. Bacteriol. 32:461–463.
Faine, S., and J. van der Hoeden. 1964. Virulence-linked colonial and morphological variation in Leptospira. J. Bacteriol. 88:1493–1496.
Farrelly, H. E., B. Adler, and S. Faine. 1987. Opsonic monoclonal antibodies against lipopolysaccharide antigens of Leptospira interrogans serovar hardjo. J. Med. Microbiol. 23:1–7.
Hanson, L. E., D. N. Tripathy, L. B. Evans, and A. D. Alexander. 1974. An unusual leptospira, serotype illini (a new serotype). Int. J. Syst. Bacteriol. 24:355–357.
Hathaway, S. C., R. B. Marshall, T. W. A. Little, S. A., Headlam, and P. J. Winter. 1985. Differentiation of reference strains of leptospires of the Pomona serogroup by cross-agglutination absorption and restriction endonuclease analysis. Res. Vet. Sci. 39:145–150.
Hindle, E., and P. B. White. 1934. A soluble specific substance in spirochaetes. Proc. Royal Soc. “B” 114:523–529.
Hovind-Hougen, K. 1979. Leptospiraceae, a new family to include Leptospira Noguchi 1917 and Leptonema gen. nov. Int. J. Syst. Bacteriol. 29:245–251.
Hovind-Hougen, K., M. Cinco, G. M. Roomans, and A. Birch-Andersen. 198la. Electron microscopy and X-ray microanalysis of a halophilic leptospire. Arch. Microbiol. 130:339–343.
Hovind-Hougen, K., W. A. Ellis, and A. Birch-Andersen. 1981b. Leptospira parva sp. nov.: some morphological and biological characters. Zentralbl. Bakteriol. Hyg. I Abt. Orig. A 250:343–354.
Ito, T., and R. Yanagawa. 1987a. Leptospiral attachment to extracellular matrix of mouse fibroblast (L929) cells. Vet. Microbiol. 15:89–96.
Ito, T., and R. Yanagawa. 1987b. Leptospiral attachment to four structural components of extracellular matrix. Jpn. J. Vet. Sci. 49:875–882.
Johnson, R. C. 1976. Comparative spirochete physiology and cellular composition, p. 39–48. In: R. C. Johnson, (ed.), The biology of parasitic spirochetes. Academic Press, New York.
Johnson, R. C. 1981. Aerobic spirochetes: the genus Leptospira, p. 582–591. In: M. P. Starr, H. Stolp, H. G. Trüper, A. Balows, and H. G. Schlegel (ed.), The prokaryotes, vol. 1, 1st ed. Springer-Verlag, Berlin.
Johnson, R. C., and S. Faine. 1984. Order I. Spirochaetales: Family II. Leptospiraceae Hovind-Hougen 1979, 245. Genus I. Leptospira Noguchi, 1917, 755, p. 62–67. In: N. R. Krieg and J. G. Holt (ed.), Bergey’s manual of systematic bacteriology, vol. 1. Williams and Wilkins, Baltimore.
Johnson, R. C., B. P. Livermore, J. K. Walby, and H. M. Jenkin. 1970. Lipids of parasitic and saprophytic leptospires. Infect. Immun. 2:286–291.
Johnson, R. C., and L. H. Muschel. 1966. Antileptospiral activity of serum. I. Normal and immune serum. J. Bacteriol. 91:1403–1409.
Jost, H. B., B. Adler, and S. Faine. 1988. Reaction of monoclonal antibodies with species specific determinants in Leptospira interrogans outer envelope. J. Med. Microbiol. 27:51–57.
Jost, B. H., B. Adler, and S. Faine. 1989. Experimental immunisation of hamsters with lipopolysaccharide antigens of Leptospira interrogans. J. Med. Microbiol. 29:115–120.
Kasarov, L. B. 1970. Degradation of the erythrocyte phospholipids and hemolysis of the erythrocytes of different animal species by leptospirae. J. Med. Microbiol. 3:29–37.
Kasarov, L. B., and L. Addamiano. 1970. Degradation of the phospholipids of the serum lipoproteins by leptospirae. J. Med. Microbiol. 2:243–248.
Kefford, B., S. Kjelleberg, and K. C. Marshall. 1983. Bacterial scavenging: utilization of fatty acids localized at a solid-liquid interface. Arch. Microbiol. 133:257–260.
Kelson, J. S., B. Adler, A. J. Chapman, and S. Faine. 1988. Identification of leptospiral flagellar antigens by gel electrophoresis and immunoblotting. J. Med. Microbiol. 26:47–53.
Kmety, E., and H. Dikken. 1988. Revised list of Leptospira serovars. University Press, Groningen, The Netherlands.
Larson, A. D., and C. D. Cox. 1957. Colonial growth of leptospirae. J. Bacteriol. 73:587–589.
Lawrence, J. J. 1951. The growth of leptospirae in semisolid media. Austral. J. Exp. Biol. Med. Sci. 29:195–199.
Le Febvre, R. B., and A. B. Thiermann. 1986. DNA homology studies of leptospires of serogroups Sejroe and Pomona from cattle and swine. Amer. J. Vet. Res. 47:959–963.
Magnarelli, L. A., J. F. Anderson, and R. C. Johnson. 1987. Cross-reactivity in serological tests for Lyme disease and other spirochetal infections. J. Infect. Dis. 156:183–188.
Masuzawa, T., R. Nakamura, T. Shimizu, Y. Iwamoto, T. Morita, and Y. Yanagihara. 1989. Immunological characteristics of the glycolipid antigen of Leptospira interrogans serovar lai. Infect. Immun. 57:2502–2506.
Millar, D. B., R. J. Chappel, and B. Adler. 1987. Detection of leptospires in biological fluids using DNA hybridisation. Vet. Microbiol. 15:71–78.
Nauman, R. K., S. C. Holt, and C. D. Cox. 1969. Purification, ultrastructure, and composition of axial filaments from Leptospira. J. Bacteriol. 98:264–280.
Nunes-Edwards, P. L., A. B. Thiermann, P. J. Bassford, and L. V. Stamm. 1985. Identification and characterization of the protein antigens of Leptospira interrogans serovar hardjo. Infect. Immun. 48:492–497.
Oie, S., K. Hironaga, A. Koshiro, H. Konishi, and Z. Yoshii. 1983. In vitro susceptibilities of five Leptospira strains to 16 antimicrobial agents. Antimicrob. Agents Chem-other. 24:905–908.
Ono, E., M. Naiki, and R. Yanagawa. 1982. Production and characterization of monoclonal antibodies to lipopolysaccharide antigen of Leptospira interrogans serovar kremastos and canicola. Zentralbl. Bakteriol. Hyg. I Abt. Orig. 252:414–424.
Ono, E., H. Takase, M. Naiki, and R. Yanagawa. 1987. Purification, characterization and serological properties of a glycolipid antigen reactive with a serovar-specific monoclonal antibody against Leptospira interrogans serovar canicola. J. Gen. Microbiol. 133:1329–1336.
Peet, R. L., A. Mercy, L. Hustas, and C. Speed. 1983. The significance of Leptospira isolated from kidneys of slaughtered pigs. Austral. Vet. J. 60:226–227.
Robinson, A. J., R. Rammadas, A. Lee, and R. B. Marshall. 1982. Differentiation of subtypes within Leptospira interrogans serovars hardjo, balcanica, and tarassovi by bacterial restriction-endonuclease DNA analysis (BRENDA). J. Med. Microbiol. 15:331–338.
Shimizu, T., E. Matsusaka, N. Nagakura, K. Takayanagi, T. Masuzawa, Y. Iwamoto, T. Morita, I. Mifuchi, and Y. Yanagihara. 1987. Chemical properties of lipopolysaccharide-like substance (LLS) extracted from Leptospira interrogans serovar canicola strain Moulton. Microbiol. Immunol. 31:717–725.
Terpstra, W. J., H. Korver, J. van Leeuwen, R L. Klatser, and A. H. J. Kolk. 1985. The classification of sejroe group serovars of Leptospira interrogans with monoclonal antibodies. Zentralbl. Bakteriol. Hyg. A. 259:498–506.
Terpstra, W. J., H. Korver, G. J. Schoone, J. van Leeuwen, C. E. Schönemann, S. de Jonge-Aglibut, and A. H. J. Kolk. 1987. Comparative classification of leptospira serovars of the Pomona group by monoclonal antibodies and restriction-endonuclease analysis. Zentralbl. Bakteriol. Hyg. A. 266:412–421.
Thompson, J. C., and B. W. Manktelow. 1986. Pathogenesis and red blood cell destruction in haemoglobinaemic leptospirosis. J. Comp. Path. 96:529–540.
van den Ingh, T. S. G. A. M., and E. G. Hartman. 1986. Pathology of acute Leptospira interrogans serotype icterohaemorrhagiae infection in the syrian hamster. Vet. Microbiol. 12:367–376.
van Eys, G. J. J. M., J. Zaal, G. J. Schoone, and W. J. Terpstra. 1988. DNA hybridization with hardjobovis-specific recombinant probes as a method for type discrimination of Leptospira interrogans serovar hardjo. J. Gen. Microbiol. 134:567–574.
van Eys, G. J. J. M., C. Gravenkamp, M. J. Gerritsen, W. Quint., M. T. E. Cornelissen, J. Ter Schegget, and W. J. Terpstra. 1989. Detection of leptospires in urine by polymerase chain reaction. J. Clin. Microbiol. 27:2258–2262.
Vinh, T., S. Faine, and B. Adler. 1984. Adhesion of leptospires to mouse fibroblasts (L929) and its enhancement by specific antibody. J. Med. Microbiol. 18:73–85.
Vinh, T., B. Adler, and S. Faine. 1986a. Ultrastructure and chemical composition of lipopolysaccharide extracted from Leptospira interrogans serovar copenhageni. J. Gen. Microbiol. 132:103–109.
Vinh, T., B. Adler, and S. Faine. 1986b. Glycolipoprotein cytotoxin from Leptospira interrogans serovar copenhageni. J. Gen. Microbiol. 132:111–123.
Vinh, T., M.-H. Shi, B. Adler, and S. Faine. 1989. Characterization and taxonomic significance of lipopolysaccharides of Leptospira interrogans serovar hardjo. J. Gen. Microbiol. 135:2663–2673.
Watt, G., L. M. Alquiza, L R. Padre, M. L. Tuazon, and L. W. Laughlin. 1988. The rapid diagnosis of leptospi- rosis: a prospective comparison of the dot enzymelinked immunosorbent assay and the genus-specific microscopic agglutination test at different stages of illness. J. Infect. Dis. 157:840–842.
Wood, J., R. C. Johnson, and K. Palin. 1981. Surface colonies of Leptospira interrogans. J. Clin. Microbiol. 13:102–105.
Yamaguchi, T., E. Ono, T. Ito, and R. Yanagawa. 1988. Restriction endonuclease DNA analysis of antigenic variants of leptospires selected by monoclonal antibodies. Microbiol. Immunol. 32:1007–1011.
Yanagawa, R., and S. Faine. 1966. Morphological and serological analysis of leptospiral structure. Nature 211:823–826.
Yanagihara, Y., and I. Mifuchi. 1968. Microfibers present in surface structure of Leptospira. J. Bacteriol. 95:2403–2406.
Yanagihara, Y., Y. Hattori, and I. Mifuchi. 1975. Purification of microfibers of Leptospira and their chemical and immunological properties, p. 347–353. In: Proceedings of the National Symposium on Leptospirosis, Leptospira and Other Spirochaeta. Cantacuzino Institute, Bucharest, Romania.
Yanagihara, Y., K. Kamisango, K. Takeda, I. Mifuchi, and I. Azuma. 1983. Identification of 4-o-methylmannose in cell wall polysaccharide of Leptospira. Microbiol. Immunol. 27:711–715.
Yasuda, P. H., A. G. Steigerwalt, K. R. Sulzer, A. F Kaufmann, E Rogers, and D. J. Brenner. 1987. Deoxyribonucleic acid relatedness between serogroups and serovars in the family Leptospiraceae with proposals for seven new Leptospira species. Int. J. Syst. Bacteriol. 37:407–415.
Yelton, D. B., and R. A. Cohen. 1986. Analysis of a cloned DNA from Leptospira biflexa serovar patoc which complements a deletion of the Escherichia coli trpE gene. J. Bacteriol. 165:41–46.
Yelton, D. B., and S. L. Peng. 1989. Identification and nucleotide sequence of the Leptospira biflexa serovar pa-toc trpE and trpG genes. J. Bacteriol. 171:2083–2089.
Zuerner, R. L., and C. A. Bolin. 1988. Repetitive sequence element cloned from Leptospira interrogans serovar hardjo type hardjo-bovis provides a sensitive diagnostic probe for bovine leptospirosis. J. Clin. Microbiol. 26:2495–2500.
Zuerner, R. L., and N. W. Charon. 1988. Nucleotide sequence analysis of a gene cloned from Leptospira biflexa serovar patoc which complements an argE defect in Escherichia coli. J. Bacteriol. 170:4548–4554.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Faine, S. (1992). The Genus Leptospira . In: Balows, A., Trüper, H.G., Dworkin, M., Harder, W., Schleifer, KH. (eds) The Prokaryotes. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-2191-1_32
Download citation
DOI: https://doi.org/10.1007/978-1-4757-2191-1_32
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4757-2193-5
Online ISBN: 978-1-4757-2191-1
eBook Packages: Springer Book Archive