The Organization of Chromosomes and Chromatin

  • Christopher L. Woodcock


The eukaryotic nucleus and its components are, in principle, ideal subjects for tomographic structural analysis. Within the nucleus, a number of crucial and closely regulated processes occur. These include DNA replication and chromatin assembly, RNA transcription, the processing and transport of mRNA and rRNA, and chromosome condensation and decondensation. Many of these events have been studied in detail at the molecular level, yet very little is known about the three-dimensional (3D) spatial framework within which they occur. Electron tomography offers direct insight into these structural and functional aspects of nuclear organization.


Tilt Angle Nucleosome Position Tomographic Reconstruction Chromatin Fiber Transcription Complex 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Christopher L. Woodcock
    • 1
  1. 1.Department of Zoology and Program in Molecular and Cellular BiologyUniversity of MassachusettsAmherstUSA

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