Transcriptional Control of the α-Crystallin Gene Family
Crystallina constitute 80–90% of the soluble protein of the ocular lens. There are a surprisingly large number of crystallin gene families; some (α- and ßγ-crystallins) are present in all vertebrate lenses, whereas others (the enzyme-crystallins) are found only in the lenses of certain species. The enzyme-crystallins are not lens-specific and appear to have a double function, i.e., as structural proteins in the lens and as metabolic enzymes in other tissues (see Wistow and Piatigorsky, 1988; Piatigorsky and Wistow, 1989). In addition to their lens-specific or lens-preferred expression, the synthesis of the crystallin polypeptides is developmentally regulated in a temporal and spatial manner in the lens (see McAvoy, 1981; Piatigorsky, 1981).
KeywordsTransgenic Mouse Hybrid Gene Small Heat Shock Protein Transient Assay Mouse Lens
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