Chromosome Abnormalities and Phenotype in Previable Fetuses

  • Dagmar K. Kalousek
  • Naomi Fitch
  • Barbara A. Paradice

Abstract

The incidence of chromosome errors in late spontaneous abortions is low (about 5%) compared to the losses during the embryonic period of development (Craver and Kalousek, 1987). Late spontaneous abortions related to chromosomal trisomies generally involve younger fetuses (9 to 14 weeks of development), whereas X chromosome monosomy and triploidies abort any time between 9 and 18 weeks. Since fetuses may be retained in utero after intrauterine death for several days to weeks, they are usually macerated and distorted by the time spontaneous abortion occurs. It is therefore good policy to initiate chromosomal studies of all retained macerated fetuses, regardless of the presence or absence of developmental defects.

Keywords

Down Syndrome Chromosome Abnormality Ventricular Septal Defect Turner Syndrome Noonan Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Dagmar K. Kalousek
    • 1
  • Naomi Fitch
    • 2
  • Barbara A. Paradice
    • 3
  1. 1.Department of PathologyThe University of British Columbia and BC Children’s HospitalVancouverCanada
  2. 2.Department of Pathology, Lady Davis Institute, Sir Mortimer B. Davis Jewish General HospitalThe University of British ColumbiaMontrealCanada
  3. 3.Embryopathology UnitBC Children’s HospitalVancouverCanada

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