Principles of Early Abortion Specimen Examination

  • Dagmar K. Kalousek
  • Naomi Fitch
  • Barbara A. Paradice


For accurate pathologic evaluation of the early aborted conceptus, all aborted tissues and a thorough obstetrical, medical, and family history are required. The need for complete clinical information is similar to that required for other types of intrauterine death. Menstrual dates are valuable for dating the gestational sac and embryo. Information about drug ingestion (e.g., anticonvulsive medication) or exposure to infection during pregnancy (e.g., rubella) is essential for directing the pathologist’s attention to a specific problem and for proper handling of the specimen. A history of previous reproductive failures or a family history of a particular congenital, morphological, or metabolic defect may significantly influence the investigative approach. An example of a consultation request form is given in Appendix II (Table II-7).


Human Embryo Chorionic Villus Abnormal Embryo Embryonic Death Open Neural Tube Defect 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Dagmar K. Kalousek
    • 1
  • Naomi Fitch
    • 2
  • Barbara A. Paradice
    • 3
  1. 1.Department of PathologyThe University of British Columbia and BC Children’s HospitalVancouverCanada
  2. 2.Department of Pathology, Lady Davis Institute, Sir Mortimer B. Davis Jewish General HospitalThe University of British ColumbiaMontrealCanada
  3. 3.Embryopathology UnitBC Children’s HospitalVancouverCanada

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