Placental Abnormalities

  • Dagmar K. Kalousek
  • Naomi Fitch
  • Barbara A. Paradice


All placentas from spontaneous abortions should be submitted for pathologic examination. The placenta plays a key role in the maintenance of pregnancy, and it is likely that it also is a major influence on the processes involved in expulsion of an aborting conceptus. For example, it has been shown that fetuses with trisomy 13 and 18 that survive to term have confined chromosomal mosaicism, with a normal diploid cell line in the cytotrophoblast (Kalousek et al., 1989). Chromosomally normal fetuses with confined placental mosaicism involving various trisomies are more likely to die in utero (Johnson et al., 1990). Because of the key role of the placenta at its interface with the maternal organism, it follows that detailed studies may provide valuable data on both intrauterine fetal survival and mechanisms of spontaneous abortion.


Spontaneous Abortion Hydatidiform Mole Complete Hydatidiform Mole Single Umbilical Artery Placental Abnormality 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Dagmar K. Kalousek
    • 1
  • Naomi Fitch
    • 2
  • Barbara A. Paradice
    • 3
  1. 1.Department of PathologyThe University of British Columbia and BC Children’s HospitalVancouverCanada
  2. 2.Department of Pathology, Lady Davis Institute, Sir Mortimer B. Davis Jewish General HospitalThe University of British ColumbiaMontrealCanada
  3. 3.Embryopathology UnitBC Children’s HospitalVancouverCanada

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