Skin Pharmacology and Dermatology

  • Andreas J. Bircher
  • Richard H. Guy
  • Howard I. Maibach
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 107)


Laser Doppler flowmetry (LDF) has many uses in pharmacologic dermatology. The topics covered in this chapter include cutaneous pharmacology and pharmacodynamics of vasoactive compounds, determination of transcutaneous drug penetration kinetics, and evaluation of the potency of penetration enhancers. Ultraviolet erythema, the effects of inflammatory mediators, irritation from chemical compounds, and patch-test allergens have been studied. Newer applications are the objective measurement of skin lesions, the control of dermatologic therapy, and comparison of the reactivity of the cutaneous microcirculation in different age and ethnic groups. This chapter presents our experience with LDF in the dermatologic and pharmacological investigations and reviews related publications.


Contact Dermatitis Laser Doppler Flowmetry Skin Blood Flow Laser Doppler Velocimetry Percutaneous Absorption 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Andreas J. Bircher
  • Richard H. Guy
  • Howard I. Maibach

There are no affiliations available

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