Abstract
The blood supply is recognized as a vital basis of bone growth and remodeling. However, preference has been given to microvascular studies in other tissues. Until recently, bone was a minor topic in the literature of the microcirculation. In 1691, Clopton Havers [1] described “small canals” transversing cortical bone. He assumed a possible vascular pathway in bone, once regarded as a lifeless supporting frame for soft tissues. Some 250 years later, fundamental investigations confirmed Havers’s theory of vascular canals and clarified the vascular topography of bone. The physiological aspects of blood flow in bone, however, are still a challenge to microvascular research. As a technique for continuous flow registration in bone, laser-Doppler flowmetry (LDF) has been found to fulfill most of the requirements for experimental research.
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Hellem, S., Salerud, E.G. (1990). Blood Flow in Bone. In: Shepherd, A.P., Öberg, P.Å. (eds) Laser-Doppler Blood Flowmetry. Developments in Cardiovascular Medicine, vol 107. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2083-9_17
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DOI: https://doi.org/10.1007/978-1-4757-2083-9_17
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