Abstract
The development of the FRTL and FRTL-5 thyroid cells (Fig. 1A) by F.S. Ambesi-Impiombato and his colleagues (1,2) moved research in the thyroid area from a concern with the thyrotropin receptor to an examination of receptor interactions or cross-talk. These cells require TSH for their growth (Fig. 1B). However, the TSH action requires the presence of insulin and serum factors, one of which we now know to be IGF-I (Fig. 1B); no single factor, TSH, insulin, or IGF-I, can reproduce the mixture of all. Further it is evident that the insulin and IGF-I actions are not identical; thus when concentrations of insulin as high as 10 micrograms per ml are present, the addition of only 50 or 100 ng/ml of IGF-I is still significantly additive to TSH and insulin in stimulating an increase in cell number.
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Perrotti, N., Rotella, C.M., Alvarez, F.V., Kohn, L.D., Taylor, S. (1989). Characterization of Receptors for Insulin and Insulin-Like Growth Factor-1 on FRTL-5 Thyroid Cells. In: Ekholm, R., Kohn, L.D., Wollman, S.H. (eds) Control of the Thyroid Gland. Advances in Experimental Medicine and Biology, vol 261. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2058-7_5
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DOI: https://doi.org/10.1007/978-1-4757-2058-7_5
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