Thyroid-Stimulating Hormone: Structure and Function

  • James A. Magner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 261)

Abstract

Thyroid-stimulating hormone (TSH) is a pituitary-derived glycoprotein of molecular weight 28,000 that is composed of two noncovalently linked subunits, α and β. TSH is chemically related to the pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as to placental chorionic gonadotropin (CG). TSH is synthesized by thyrotropes of the anterior pituitary and stored in secretory granules. TSH is released into the circulation in a regulated manner, binds to thyroid cells and activates them to release thyroid hormones.

Keywords

Thyroid Hormone Glycoprotein Hormone Hypothyroid Mouse High Mannose Oligosaccharide Pituitary Glycoprotein Hormone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • James A. Magner
    • 1
  1. 1.Michael Reese HospitalUniversity of ChicagoChicagoUSA

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