Thyroid Specific Gene Expression

  • Alison J. Sinclair
  • Renata Lonigro
  • Donato Civitareale
  • Roberto Di Lauro
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 261)

Abstract

The biosynthesis of thyroid hormones requires the iodination and coupling of two tyrosine residues. During evolution specialized cells within the thyroid gland have developed to accomplish this task. The follicular cells of the thyroid gland are arranged in a characteristic tridimensional structure which consists of a sphere of follicular cells surrounding a lumen. Iodine is transported from the bloodstream into the follicular cells by a thyroid specific iodine channel, and subsequently reaches the lumen of the follicle. Two further thyroid specific functions are present in the follicle to assist hormone synthesis: a thyroid specific peroxidase (TPO) and thyroglobulin (Tg). The peroxidase has two functions: it catalyzes the incorporation of iodine onto some of the tyrosyl residues of the thyroglobulin molecule and it is required for the coupling of a subset of the iodinated residues to form the hormones. Upon interaction of Thyroid Stimulating Hormone (TSH) with its receptor the modified thyroglobulin is reabsorbed from the follicular lumen, then it is degraded within the follicular cells and free hormone is released in the bloodstream1.

Keywords

Thyroid Stimulate Hormone Follicular Cell Thyroid Cell Chloramphenicol Acetyl Transferase Thyroglobulin Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Alison J. Sinclair
    • 1
  • Renata Lonigro
    • 1
  • Donato Civitareale
    • 1
  • Roberto Di Lauro
    • 1
  1. 1.European Molecular Biology LaboratoryHeidelbergGermany

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