Abstract
Our laboratory has been involved in the study of thyroid regulation at the cellular level for many years. The complex picture emerging from these studies leads to conclusions of general relevance. The regulation of the thyroid cell was once a classical example of the concept one hormone — one cell type — one intracellular secondary messenger with its pleiotypic effects. It should now rather be considered as a network of crosslinked regulatory steps where the extracellular and intracellular signal-molecules act on their receptors as bits of information in an electronic circuit, i.e., express on/off regulations with no definite general physiological meaning per se. Such networks differ from one cell type to another and for a given cell type from one species to another. In the case of the thyroid many apparent discrepancies in the literature are explained if this is taken into account. In this presentation, we wish to draw mainly on the results of our group to illustrate this point with regard to the regulation of function, proliferation and differentiation of the thyroid cell.
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Dumont, J.E., Takeuchi, A., Lamy, F., Gervy-Decoster, C., Cochaux, P., Roger, P., Van Sande, J., Lecocq, R., and Mockel, J. Thyroid control: an example of a complex cell regulation network. Adv. Cyclic Nucl. Res., 14: 479 (1981).
Lamy, F., Roger, P., Contor, L., Reuse, S., Raspé, E., Van Sande, J., and Dumont, Control of thyroid cell proliferation: the example of the dog thyrocyte, Horm. Cell Regul. 153 (11): 169 (1987)
Björkman, U, and Ekholm R. Accelerated exocytosis and H202 generation in isolated thyroid follicles enhance protein iodination, Endocrinology 122: 488 (1988)
Corvilain, B., Van Sande, J. and Dumont, J.E. Inhibition by iodide of iodide binding to porteins: the “Wolff-Chaikoff-effect” is caused by inhibition of H202 generation. Biochem. Biophys. Res. Commun. 154: 1287 (1988)
Sheela Rani C.S., Boyd A.E., and Field, J.B. Effects of acetylcholine, TSH and other stimulators on intracellular calcium concentration in dog thyroid cells. Biochem. Biophys. Res. Commun. 131: 1041 (1985)
Raspé, E., Roger, P., and Dumont, J.E. Carbamylcholine, TRH, PGF2 and fluoride enhance free intracellular Ca++ and Ca++ translocation in dog thyroid cells. Biochem. Biophys. Res. Commun. 141: 569 (1986)
Graff, I., Mockel, J., Laurent, E., Erneux, C., and Dumont, J.E. Carbachol and sodium fluoride, but not TSH, stimulate the generation of inositol phosphates in the dog thyroid. FEBS Letters 210: 204 (1987)
Decoster, C., Mockel, J., Van Sande, J., Unger, J., and Dumont, J.E. The role of calcium and guanosine 3’:5’-monophosphate in the action of acetylcholine on thyroid metabolism. Eur. J. Biochem. 104: 199 (1980)
Unger, J., Ketelbant, P., Erneux, C., Mockel, J., and Dumont, J.E. Mechanism of cholinergic inhibition of dog thyroid secretion in vitro. Endocrinology 114: 1266 (1984)
Mockel, J., Van Sande, J., Decoster, C., and Dumont, J.E. Tumor promoters as probes of protein kinase C in dog thyroid cell: inhibition of the primary effects of carbamylcholine and reproduction of some distal effects. Metabolism 36: 137 (1987).
Van Sande, J., Mockel, Boeynaems, J.M., Dor, P., Andry, G., and Dumont, J.E. Regulation of cyclic nucleotide and prostaglandin formation in normal human thyroid tissue and in autonomous nodules. J. Clin. Endocrinol. Metab. 50: 776 (1980)
Van Sande, J., Lamy, F., Lecocq, R., Mirkine, N., Rocmans, P., Cochaux, P., Mockel, J. and Dumont J.E. Pathogenesis of autonomous thyroid nodules: in vitro study of iodine and adenosine 3’,5’-monophosphate metabolism. J. Clin. EndocrinoL. metab. 66: 570 (1988)
Laurent, E., Mockel, J., Van Sande, J., Graff, I., and Dumont, J.E. Dual activation by thyrotropin of the phosphoLipase C and cyclic AMP cascades in human thyroid. Mol. Cell. Endocr. 52: 273 (1987)
Libert, F., Parmentier, M;, Lefort, A., Dinsart, C., Van Sande, J., Maenhaut, C., Simons, M.J., Dumont, J.E., and Vassart, G. Selective amplification and cloning of four new members of the G protein-coupled receptor family. Science (in press) (1989)
Dumont, J.E., Jauniaux, J.C., Roger, P.P. The cyclic AMP-mediated stimulation of cell proliferation. Trends Biochem. Sci. 14: 67 (1989)
Baserga, R. 1985 The Biology of Cell Reproduction, Harvard University Press.
Valente, W.A., Vitti, P., Kohn, L.D., Brandi, M.L., Rotella, C.M., Toccafondi, R., Tramontano, D., Aloj, S.M., Ambesi-Impiombato, F.S. The relationship of growth and adenylate cyclase activity in cultured thyroid cells. Separate bioeffects of thyrotropin. Endocrinology 112: 71 (1983)
Dere, W.H., and Rapoport, B. Control of growth in cultured rat thyroid cells. Mol. Cell. Endocrinol. 44: 195 (1986)
Contor, L., Lamy, F., Lecocq, R., Roger, P.P. and Dumont, J.E. Differential protein phosphorylation in induction of thyroid cell proliferation by thyrotropin, epidermal growth factor, or phorbol ester. Mol. Cell. Endocrinol 8: 2494 (1988)
Lamy, F., Roger, P.P., Lecocq, R., and Dumont, J.E. Differential protein synthesis in the induction of thyroid cell proliferation by thyrotropin, epidermal growth factor or serum. Eur. J. Biochem. 155: 265 (1986)
Roger, P.P., Taton, M., Van Sande, J., and Dumont J.E. Mitogenic effects of thyrotropin and cyclic AMP in differentiated human thyroid cells in vitro. J. Clin. Endocrinol. Metab. 66: 1158 (1988)
Roger, P.P., Servais, P., and Dumont, J.E. Induction of DNA synthesis in dog thyrocytes in primary culture: synergistic effects of thyrotropin and cyclic AMP with epidermal growth factor and insulin. J. Cell. Physiol. 130: 587 (1987)
Lefort, A., Lecocq, R., Libert, F., Lamy, F., Swillens, S., Vassart, G., and Dumont, J.E. Cloning and sequencing of a calcium-binding protein regulated by cyclic AMP in the thyroid. EMBO J. 8: 111 (1989)
Goyens, P., Golstein, J., Nsombola, B., Vis, H., and Dumont, J.E. Selenium deficiency as a possible factor in the pathogenesis of myxoedematous endemic cretinism. Acta Endocrinol. 114: 497 (1987)
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Dumont, J.E. et al. (1989). Transducing Systems in the Control of Human Thyroid Cell Function, Proliferation and Differentiation. In: Ekholm, R., Kohn, L.D., Wollman, S.H. (eds) Control of the Thyroid Gland. Advances in Experimental Medicine and Biology, vol 261. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2058-7_15
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DOI: https://doi.org/10.1007/978-1-4757-2058-7_15
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