Abstract
Previous reports (1–11) have defined the importance of the Ca/phosphoinositide/arachidonic acid signal system to both the function and growth of FRTL-5 rat thyroid cells and to the action of both thyrotropin (TSH) and alpha-1 adrenergic agents in these cells. Thus evidence has been presented that norepinephrine and TSH could increase degradation of phosphatidylinositol 4,5-bisphosphate (PIP2) (1) with the concomitant formation of diacyiglycerol and IP3 (2). This action was accompanied by increases in cytosolic Ca++ (3), arachidonic acid release from the cells (4, 5) and the action of arachidonic acid metabolites in processes important to thyroid hormone formation and growth (4–11).
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Tahara, K., Saji, M., Aloj, S.M., Kohn, L.D. (1989). The Arachidonic Acid Signal System in the Thyroid: Regulation by Thyrotropin and Insulin/IGF-I. In: Ekholm, R., Kohn, L.D., Wollman, S.H. (eds) Control of the Thyroid Gland. Advances in Experimental Medicine and Biology, vol 261. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2058-7_12
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