Abstract
The concept that inositol phospholipid hydrolysis is a very early event and is responsible for transducing the effect of hormone-receptor stimulation to the cell interior is now widely accepted. The activation of these specific receptors stimulates phospholipase C which degrades membrane-bound phosphatidylinositol 4,5-bisphosphate to produce two second messengers: inositol 1,4,5-trisphosphate, which can liberate Ca2+ from intracellular stores, and 1,2-diacylglycerol, which activates protein kinase C. The membrane-bound transducer that relates the message from the receptor to the phospholipase C seems to be a specific GTP-binding protein, that is referred to as Gp, where p stands for phosphoinositide.
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Lapetina, E.G. (1989). The Inositide and Arachidonic Acid Signal System. In: Ekholm, R., Kohn, L.D., Wollman, S.H. (eds) Control of the Thyroid Gland. Advances in Experimental Medicine and Biology, vol 261. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2058-7_11
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DOI: https://doi.org/10.1007/978-1-4757-2058-7_11
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