The Inositide and Arachidonic Acid Signal System

  • Eduardo G. Lapetina
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 261)


The concept that inositol phospholipid hydrolysis is a very early event and is responsible for transducing the effect of hormone-receptor stimulation to the cell interior is now widely accepted. The activation of these specific receptors stimulates phospholipase C which degrades membrane-bound phosphatidylinositol 4,5-bisphosphate to produce two second messengers: inositol 1,4,5-trisphosphate, which can liberate Ca2+ from intracellular stores, and 1,2-diacylglycerol, which activates protein kinase C. The membrane-bound transducer that relates the message from the receptor to the phospholipase C seems to be a specific GTP-binding protein, that is referred to as Gp, where p stands for phosphoinositide.


Arachidonic Acid Human Platelet Pertussis Toxin Inositol Phosphate Hydroxy Acid 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Eduardo G. Lapetina
    • 1
  1. 1.Division of Cell BiologyBurroughs Wellcome Co.Research Triangle ParkUSA

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