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ADP Ribosylation and G Protein Regulation in the Thyroid

  • Chapter
Control of the Thyroid Gland

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 261))

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Abstract

Although most of the metabolic effects of TSH on the thyroid reflect its activation of the adenylate cyclase-cAMP system (1), other signalling systems mediate the effect of other agonists such as acetylcholine (2) and phorbol esters (3). Furthermore effects of TSH on desensitization (4) and 32P incorportation into phospholipids (1) are not mediated by cAMP. The phosphatidylinositol 4,5-bisphosphate cascade which increases intracellular Ca2+ and activates protein kinase C is present in the thyroid and may be important for the regulation of several metabolic effects (5–9). ADP ribosylation of various proteins is another possible signalling system for cell regulation (10–13). Although this process may involve either poly ADP ribosylation or mono ADP ribosylation, the present discussion will be limited to the latter process.

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Authors and Affiliations

  1. Diabetes Research Laboratory St. Lukes Episcopal Hospital Department of Medicine, Baylor College of Medicine, Houston, TX, 77030, USA

    James B. Field, Fernando Ribeiro-Neto, Madoka Taguchi, William Deery, C. S. Sheela Rani & Daniela Pasquali

Authors
  1. James B. Field
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  2. Fernando Ribeiro-Neto
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  3. Madoka Taguchi
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  4. William Deery
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  5. C. S. Sheela Rani
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  6. Daniela Pasquali
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Editor information

Editors and Affiliations

  1. University of Göteborg, Göteborg, Sweden

    Ragnar Ekholm

  2. National Institutes of Health, Bethesda, Maryland, USA

    Leonard D. Kohn  & Seymour H. Wollman  & 

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© 1989 Springer Science+Business Media New York

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Field, J.B., Ribeiro-Neto, F., Taguchi, M., Deery, W., Rani, C.S.S., Pasquali, D. (1989). ADP Ribosylation and G Protein Regulation in the Thyroid. In: Ekholm, R., Kohn, L.D., Wollman, S.H. (eds) Control of the Thyroid Gland. Advances in Experimental Medicine and Biology, vol 261. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2058-7_10

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  • DOI: https://doi.org/10.1007/978-1-4757-2058-7_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-2060-0

  • Online ISBN: 978-1-4757-2058-7

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