ADP Ribosylation and G Protein Regulation in the Thyroid

  • James B. Field
  • Fernando Ribeiro-Neto
  • Madoka Taguchi
  • William Deery
  • C. S. Sheela Rani
  • Daniela Pasquali
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 261)


Although most of the metabolic effects of TSH on the thyroid reflect its activation of the adenylate cyclase-cAMP system (1), other signalling systems mediate the effect of other agonists such as acetylcholine (2) and phorbol esters (3). Furthermore effects of TSH on desensitization (4) and 32P incorportation into phospholipids (1) are not mediated by cAMP. The phosphatidylinositol 4,5-bisphosphate cascade which increases intracellular Ca2+ and activates protein kinase C is present in the thyroid and may be important for the regulation of several metabolic effects (5–9). ADP ribosylation of various proteins is another possible signalling system for cell regulation (10–13). Although this process may involve either poly ADP ribosylation or mono ADP ribosylation, the present discussion will be limited to the latter process.


Cholera Toxin Pertussis Toxin Thyroid Cell Bovine Thyroid Arginine Methyl Ester 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • James B. Field
    • 1
  • Fernando Ribeiro-Neto
    • 1
  • Madoka Taguchi
    • 1
  • William Deery
    • 1
  • C. S. Sheela Rani
    • 1
  • Daniela Pasquali
    • 1
  1. 1.Diabetes Research Laboratory St. Lukes Episcopal Hospital Department of MedicineBaylor College of MedicineHoustonUSA

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