Canine Kidneys: Changes in Blood and Urine Chemistry After Exposure to Extracorporeal Shock Waves
The upper poles of the left kidneys and the lower poles of the right kidneys of eight mongrel dogs were exposed to 1,500 shock waves at 18 kV in the human extracorporeal lithotripsy unit at the Urological Clinic of University Hospital in Zurich. Various serum and urine laboratory evaluations were performed at one hour, at 24 to 36 hours, at seven to 11 days, and at three to six months after exposure to shock waves. These parameters were also monitored in two control animals.
In serum a transient decrease of calcium (Ca), an immediate increase of lactic dehydrogenase (LDH), serum glutamic-oxaloacetic transaminase (SCOT), serum glutamic-pyruvic transaminase (SGPT), and a delayed increase of alkaline phosphatase were observed. Creatinine (Cr), blood urea nitrogen (BUN), sodium (Na), potassium (K) and the amylase enzymes remained within normal limits. In urine a decrease of Cr levels and an increase of glucose excretion were noted. Those changes appear to represent a relatively mild and transient damage of renal cells and do not reflect the occasionally serious morphological changes observed after shock wave exposure.
KeywordsShock Wave Blood Urea Nitrogen Shock Wave Lithotripsy Extracorporeal Shock Wave Lithotripsy Shock Wave Treatment
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