Susceptibility of Renal Cell Carcinoma (RCC 7860) to In Situ Extracorporeal Shock Wave Neoplasmotripsy

  • Ali H. Mardan
  • Stefan A. Loening


In vivo susceptibility of renal cell carcinoma (RCC 7860) to shock waves was examined in a series of experiments in an athymic rat model. Tumors were treated with 800 and 1,600 shock waves at 15 kV generated by the Dornier XL1 experimental lithotripter. Treated tumors demonstrated severe hemorrhage, infarct, necrosis, cellular infiltration, and a delay in tumor growth.


  1. 1.
    Laudone VP, Morgan TR, Huryk RF, et al: Cytotoxicity of high energy shock waves: methodologic considerations. J Urol 141: 965, 1989.PubMedGoogle Scholar
  2. 2.
    Russo P Stephenson RA, Mies C, et al: High energy shock waves suppress tumor growth in vitro and in vivo. J Urol 135:626, 1986.Google Scholar
  3. 3.
    Morgan TR, Laudone VP, Heston WDW, et al: Free radical production by high energy shock waves: comparison with ionizing irradiation. J Urol 139: 186, 1988.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Ali H. Mardan
    • 1
  • Stefan A. Loening
    • 1
  1. 1.Department of UrologyUniversity of Iowa Hospitals and ClinicsIowa CityUSA

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