The Application of Molecular Biology to the Development of Novel Vaccines

  • P. J. Kniskern
  • A. Hagopian
  • P. Burke
  • N. Dunn
  • D. L. Montgomery
  • L. D. Schultz
  • C. A. Schulman
  • C. E. Carty
  • R. Z. Maigetter
  • D. E. Wampler
  • E. D. Lehman
  • S. Yamazaki
  • D. J. Kubek
  • E. A. Emini
  • W. J. Miller
  • W. M. Hurni
  • R. W. Ellis

Abstract

Before the dawn of molecular biology and recombinant DNA technology, vaccines were essentially natural products. Such vaccines comprise live attenuated disease agents, killed organisms, or biochemically isolated subcomponents or subfractions of the disease causing agent. The fact that these classical vaccines are natural products ensured that, if sufficient care were taken (during attenuation, inactivation, or subunit isolation), the important protective epitopes represented on the disease agent could be preserved on the vaccine candidate in proper immunogenic form.

Keywords

Chronic Carrier Antigen Productivity Master Seed Yeast Expression System GAL4 Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • P. J. Kniskern
    • 1
  • A. Hagopian
    • 1
  • P. Burke
    • 1
  • N. Dunn
    • 1
  • D. L. Montgomery
    • 1
  • L. D. Schultz
    • 1
  • C. A. Schulman
    • 1
  • C. E. Carty
    • 1
  • R. Z. Maigetter
    • 1
  • D. E. Wampler
    • 2
  • E. D. Lehman
    • 1
  • S. Yamazaki
    • 2
  • D. J. Kubek
    • 2
  • E. A. Emini
    • 1
  • W. J. Miller
    • 1
  • W. M. Hurni
    • 1
  • R. W. Ellis
    • 1
  1. 1.Departments of Virus and Cell BiologyMerck Sharp & Dohme Research LaboratoriesWest PointUSA
  2. 2.Biochemical Process Research and DevelopmentMerck Sharp & Dohme Research LaboratoriesWest PointUSA

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