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Haemophilus b Oligosaccharide-CRM197 and Other Haemophilus b Conjugate Vaccines: A Status Report

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Immunobiology of Proteins and Peptides V

Abstract

Haemophilus influenzae type b (Haemophilus b) is a major cause of life-threatening and debilitating diseases in infants and young children. In the United States, it is the most common cause of bacterial meningitis, and also causes other invasive diseases, such as epiglottitis, septic arthritis, cellulitis, pneumonia and bacteremia. In 1985, United States Public Health officials estimated that, despite the availability of potentially effective antibiotics and medical care, up to 1 in every 200 children in the USA develops an invasive Haemophilus b disease before the age of five years (Cochi et al., 1985). The 1985 report by the U.S. National Academy of Science on establishing vaccine priorities in the United States (NRC, 1985) estimated the annual vaccine preventable costs of Haemophilus b disease to be approximately 425 million dollars, and ranked Haemophilus b vaccine among the highest priorities for needed new vaccines.

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Authors and Affiliations

  1. Praxis Biologics, Inc., Rochester, New York, USA

    David H. Smith, Dace Viceps Madore, Ronald J. Eby & Cynthia L. Johnson

  2. University of Rochester Medical Center, Rochester, New York, USA

    Porter W. Anderson & Richard A. Insel

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  1. David H. Smith
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  2. Dace Viceps Madore
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  3. Ronald J. Eby
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  4. Porter W. Anderson
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  5. Richard A. Insel
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  6. Cynthia L. Johnson
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Editors and Affiliations

  1. Baylor College of Medicine, Houston, Texas, USA

    M. Zouhair Atassi

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© 1989 Springer Science+Business Media New York

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Smith, D.H., Madore, D.V., Eby, R.J., Anderson, P.W., Insel, R.A., Johnson, C.L. (1989). Haemophilus b Oligosaccharide-CRM197 and Other Haemophilus b Conjugate Vaccines: A Status Report. In: Atassi, M.Z. (eds) Immunobiology of Proteins and Peptides V. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2046-4_6

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  • DOI: https://doi.org/10.1007/978-1-4757-2046-4_6

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