The Genetics of the Immune Response to Trichinella spiralis Antigens in the Mouse
The production and successful utilization of a defined vaccine against a parasitic infection requires an understanding of the complex processes which occur during the development of most parasites, including the stage of the life cycle which can be effectively combatted by the host’s immune system. For the activation of the host’s immune system against any antigen there are many genetically controlled physical parameters involved, of which probably the most crucial are the interactions of the T cell receptor and the antigen/Major Histocompatibility Complex (MHC) molecules. In the case of many parasites, these particular molecular interactions have only recently been investigated. Although for several years it had been appreciated that there is a significant genetic element controlling the host’s immune response to parasites, the actual nature of these controlling elements had not been elucidated (Wassom, 1985; Behnke and Robinson, 1985; Wakelin, 1985). However, recent appraisals of trends and patterns in the genetic make-up of hosts which can be categorized as good or bad responders to particular parasites has led us to realize that the known genotype of animals which respond to parasitic infections are not just epiphenomena but actually are an indication of controlling molecular properties. This is particularly true of the immune response to Trichinella spiralis in the mouse, the host/parasite system which has revealed the most data concerning the significance of the host genotype (Wassom et al., 1984).
KeywordsMajor Histocompatibility Complex Adult Worm Host Genotype Muscle Larva Newborn Larva
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- Almond, N.M. and Parkhouse, R.M.E. (1985) Nematode Antigens. IN: Current Topics in Microbiology and Immunology 120: Parasite Antigens in Protection, Diagnosis and Escape. Springer-Verlag, Berlin,Heidelberg, pp. 173.Google Scholar
- Coffman, R., Ohara, J., Bond, M., Carty, J., Zlotnik, A. and Paul, W.E. (1986) B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide activated B cells. J. Immunol. 136:4358.Google Scholar
- Coffman, R.L., Seymour, B.W.P., Lebman, D.A., Hiraki, D.D., Christiansen, J.A., Shrader, B., Cherwinski, H.M., Savelkoul, H.F.J., Finkelman, F.D., Bond, M.W. and Mosmann, T.R. (1988) The role of helper T cell products in mouse B cell differentiation and isotype regulation. Immunol. Rev. 102:5.PubMedCrossRefGoogle Scholar
- Golinska, Z., and Bany, J. (1976) Serum immunoglobulins in inbred mice strains infected with Trichinella spiralis and Trichinella pseudospiralis. In: Trichinellosis, Kim, C., and Pawlowski, A., eds. University of New England Press, Hanover, NH, p. 151.Google Scholar
- James, E.R., and Denham, D.A. (1974) The stage specificity of the immune response to Trichinella spiralis. In: Trichinellosis, Kim, C., eds. Intent Publishing, New York, p. 345.Google Scholar
- Maizels, R.M., Kennedy, M.W., Meghji, M., Robertson, B.D. and Smith, H.V. (1987) Shared carbohydrate epitopes on distinct surface and secreted antigens of the parasitic nematode Tonorara canis. Journal of Immunology 139:207–214.Google Scholar
- Mossmann, T.R., Sherwinski, H., Bond, M.W., Giedlin, M.A. and Coffman, R.L. (1986) Two types of murine helper T cell clones. 1) Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348.Google Scholar
- Murphy, D.B., Jones, P.P., Loken, M.R. and McDevitt, H.O. (1980) Interaction between I region loci influences the expression of a cell surface la antigen. Proc. Natl. Acad. Sci. USA 77:5405.Google Scholar
- Robinson, M., Benhke, J.M. and Williams, D.J.L. (1988) Immunity to Heligmosomoides polygyrus (Nematospiroides dubius): survival or rejection of adult worms following transplantation to mice refractory to larval challenge. J. Helminthol. (in press).Google Scholar
- Wassom, D.L. (1985) Genetic control of the host response to parasite helminth infections. In: Genetic Control of Host Resistance to Infection and Malignancy (Skamene, E., ed.) Alan R. Liss, New York, p. 449.Google Scholar
- Wassom, D.L., David, C.S. and Gleich, G.J. (1980) MHC linked genetic control of the immune response to parasites: Trichinella spiralis in the mouse. In: Genetic Control of Natural Resistance to Infection and Malignancy (Eds. E. Skamene, P.A.L. Kongshown and M. Landy) Academic Press, Inc., New York, p. 75.CrossRefGoogle Scholar
- Williams, D.J.L. and Behnke, J.M. (1983) Host protective antibodies and serum immunoglobulin isotypes in mice chronically infected or repeatedly immunized with the nematode parasite Nematospiroides dubius. Immunology 348:34.Google Scholar