Abstract
Antigen mimicry by anti—idiotypic internal images offers one approach to vaccine development and immune modulation. However, the rational design of internal image vaccines and an understanding of idiotypic interactions will depend upon a precise understanding of the rules which govern antigen recognition and of the structural basis for internal image expression. Previous studies using the reovirus hemagglutinin and a synthetic peptide (GAT) identified determinants in antibody internal image variable (V) regions that appeared to match continuous sequences within the respective antigens (Ollier et al., 1985 ; Bruck et al., 1986).
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© 1989 Springer Science+Business Media New York
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Metzger, D.W., Naeve, C.W., Van Cleave, V.H. (1989). Epitope Mimicry by Anti-Idiotype Sequences in Reverse Orientation. In: Atassi, M.Z. (eds) Immunobiology of Proteins and Peptides V. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2046-4_17
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DOI: https://doi.org/10.1007/978-1-4757-2046-4_17
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