Characterization of a Synthetic Envelope Peptide of SRV-1 and SRV-2 Virus That Specifically Binds Rhesus Anti-SRV-1 and Anti-SRV-2 Neutralizing Antibodies
Currently, 5 distinct Simian type D retrovirus serotypes have been defined: SRV-1 (Calif., New Eng.), SRV-2 (2R, 2C), SRV-3 (MPMV), SRV-4 (Calif. Cyno), and SRV-5 (Chinese). Neutralizing antibodies made against the indicated Simian viruses do not cross react. Thus, we may be able to produce synthetic envelope peptides specific for each Simian virus serotype and make antibodies against the neutralizing epitopes. The experiments presented here with SRV-1 and SRV-2 viruses represent our attempts to develop a model approach for the preparation of synthetic envelope peptide vaccines.
KeywordsSynthetic Peptide Acquire Immune Deficiency Syndrome Raji Cell Simian Virus Cyanogen Bromide
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