Abstract
A large variety of substances have the property of regulating the immune system, by increasing or depressing the response to antigens after interaction with suitable cellular components. Recent reviews describe numerous natural and synthetic peptide endowed with immunomodulatory activity (Werner et al., 1986; Werner, 1987).
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Antoni, G., Presentini, R., Perin, F., Tagliabue, A., Ghiara, P., Censini, S., Volpini, G., Villa, L., and Boraschi, D., 1986, A short synthetic peptide fragment of human interleukin 1 with immunostimulatory but not inflammatory activity, J. Immunol., 137:3201.
Auron, P. E., Webb, A. C., Rosenwasser, L.J., Mucci, S. F., Rich, A., Wolff, S. M., and Dinarello, C. A., 1984, Nucleotide sequence of human monocyte interleukin 1 precursor cDNA, Proc. Natl. Acad. Sci. USA, 81:7907.
Boraschi, D., Nencioni, L., Villa, L., Censini, S., Bossu’, P., Ghiara, P., Presentini, R., Perin, F., Frasca, D., Doria, G., Forni, G., Musso, T., Giovarelli, M., Ghezzi, P., Bertini, R., Besedovsky, H. O., del Rey, A., Sipe, J. D., Antoni, G., Silvestri, S. and Tagliabue, A., 1988, In vivo stimulation and restoration of the immune response by the noninflammatory fragment 163–171 of human IL-1 β, J. Exp. Med., 168:675.
Cunningham, A. J., and Szenberg, A., 1968, Further improvements in the plaque technique for detecting single antibody-forming cells, Immunology, 14:599.
Dinarello, C. A., 1988, Biology of interleukin 1, FASEB J., 2:108.
Hopp, T. P., 1984, Protein antigen conformation: folding patterns and predictive algorithms; selection of antigenic and immunogenic peptides, in: “Synthetic Antigens,” P. Neri, and S. Piazzi, eds., Annali Sclavo, Siena.
Hopp, T. P., 1986, Protein surface analysis. Methods for identifying antigenic determinants and other interaction sites, J. Immunol. Meth., 88:1.
March, C. J., Mosley, B., Larsen, A., Cerretti, D. P., Braedt, G., Price, V., Gillis, S., Henney, C. S., Kronheim, S. R., Grabstein, K., Conlon, P. J., Hopp, T. P., and Cosman, D., 1985, Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs, Nature, 315:641.
Nencioni, L., Villa, L., Tagliabue, A., Antoni, G., Presentini, R., Perin, F., Silvestri, S, and Boraschi, D., 1987, In vivo immunostimulatory activity of the 163–171 peptide of human IL-1 β, J. Immunol., 139:800.
Perin, F., Presentini, P., and Antoni, G., 1987, Single-step high-yield purification of a synthetic peptide fragment of human interleukin 1 by preparative high-performance liquid chromatography, J. Chromatography, 397:365
Priestle, J. P., Schar, H. -P., and Grutter, M. G., 1988, Crystal structure of the cytokine interleukin 1 β, EMBO J. 7:339.
Rupp, E. A., Cameron, P. M., Ranawat, C. S., Schmidt, J. A., and Bayne, E. K., 1986, Specific bioactivities of monocyte-derived interleukin 1 α and interleukin 1 β are similar to each other on cultured murine thymocytes and on cultured human connective tissue cells, J. Clin. Invest., 78:836
Staruch, M. J., and Wood, D. D., 1983, The adjuvanticity of interleukin 1 in vivo, J. Immunol., 130:2191.
Werner, G. H., Floc’h, F, Migliore-Samour, D., and Jolles, P., 1986, Immunomodulating peptides, Experientia, 42:521.
Werner, G. H., 1987, Natural and synthetic peptides (other than neuropeptides) endowed with immunomodulating activities, Immunology Letters, 16:363.
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Antoni, G. et al. (1989). Interleukin 1 and Its Synthetic Peptides as Adjuvants for Poorly Immunogenic Vaccines. In: Atassi, M.Z. (eds) Immunobiology of Proteins and Peptides V. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2046-4_12
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DOI: https://doi.org/10.1007/978-1-4757-2046-4_12
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