Interleukin 1 and Its Synthetic Peptides as Adjuvants for Poorly Immunogenic Vaccines

  • G. Antoni
  • R. Presentini
  • F. Perin
  • L. Nencioni
  • L. Villa
  • S. Censini
  • P. Ghiara
  • G. Volpini
  • P. Bossu’
  • A. Tagliabue
  • D. Boraschi

Abstract

A large variety of substances have the property of regulating the immune system, by increasing or depressing the response to antigens after interaction with suitable cellular components. Recent reviews describe numerous natural and synthetic peptide endowed with immunomodulatory activity (Werner et al., 1986; Werner, 1987).

Keywords

Keyhole Limpet Hemocyanin Adjuvant Effect Hydrochloride Salt Beta Sheet Immunostimulatory Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Antoni, G., Presentini, R., Perin, F., Tagliabue, A., Ghiara, P., Censini, S., Volpini, G., Villa, L., and Boraschi, D., 1986, A short synthetic peptide fragment of human interleukin 1 with immunostimulatory but not inflammatory activity, J. Immunol., 137:3201.PubMedGoogle Scholar
  2. Auron, P. E., Webb, A. C., Rosenwasser, L.J., Mucci, S. F., Rich, A., Wolff, S. M., and Dinarello, C. A., 1984, Nucleotide sequence of human monocyte interleukin 1 precursor cDNA, Proc. Natl. Acad. Sci. USA, 81:7907.PubMedCrossRefGoogle Scholar
  3. Boraschi, D., Nencioni, L., Villa, L., Censini, S., Bossu’, P., Ghiara, P., Presentini, R., Perin, F., Frasca, D., Doria, G., Forni, G., Musso, T., Giovarelli, M., Ghezzi, P., Bertini, R., Besedovsky, H. O., del Rey, A., Sipe, J. D., Antoni, G., Silvestri, S. and Tagliabue, A., 1988, In vivo stimulation and restoration of the immune response by the noninflammatory fragment 163–171 of human IL-1 β, J. Exp. Med., 168:675.PubMedCrossRefGoogle Scholar
  4. Cunningham, A. J., and Szenberg, A., 1968, Further improvements in the plaque technique for detecting single antibody-forming cells, Immunology, 14:599.PubMedGoogle Scholar
  5. Dinarello, C. A., 1988, Biology of interleukin 1, FASEB J., 2:108.PubMedGoogle Scholar
  6. Hopp, T. P., 1984, Protein antigen conformation: folding patterns and predictive algorithms; selection of antigenic and immunogenic peptides, in: “Synthetic Antigens,” P. Neri, and S. Piazzi, eds., Annali Sclavo, Siena.Google Scholar
  7. Hopp, T. P., 1986, Protein surface analysis. Methods for identifying antigenic determinants and other interaction sites, J. Immunol. Meth., 88:1.CrossRefGoogle Scholar
  8. March, C. J., Mosley, B., Larsen, A., Cerretti, D. P., Braedt, G., Price, V., Gillis, S., Henney, C. S., Kronheim, S. R., Grabstein, K., Conlon, P. J., Hopp, T. P., and Cosman, D., 1985, Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs, Nature, 315:641.PubMedCrossRefGoogle Scholar
  9. Nencioni, L., Villa, L., Tagliabue, A., Antoni, G., Presentini, R., Perin, F., Silvestri, S, and Boraschi, D., 1987, In vivo immunostimulatory activity of the 163–171 peptide of human IL-1 β, J. Immunol., 139:800.PubMedGoogle Scholar
  10. Perin, F., Presentini, P., and Antoni, G., 1987, Single-step high-yield purification of a synthetic peptide fragment of human interleukin 1 by preparative high-performance liquid chromatography, J. Chromatography, 397:365CrossRefGoogle Scholar
  11. Priestle, J. P., Schar, H. -P., and Grutter, M. G., 1988, Crystal structure of the cytokine interleukin 1 β, EMBO J. 7:339.PubMedGoogle Scholar
  12. Rupp, E. A., Cameron, P. M., Ranawat, C. S., Schmidt, J. A., and Bayne, E. K., 1986, Specific bioactivities of monocyte-derived interleukin 1 α and interleukin 1 β are similar to each other on cultured murine thymocytes and on cultured human connective tissue cells, J. Clin. Invest., 78:836PubMedCrossRefGoogle Scholar
  13. Staruch, M. J., and Wood, D. D., 1983, The adjuvanticity of interleukin 1 in vivo, J. Immunol., 130:2191.PubMedGoogle Scholar
  14. Werner, G. H., Floc’h, F, Migliore-Samour, D., and Jolles, P., 1986, Immunomodulating peptides, Experientia, 42:521.PubMedCrossRefGoogle Scholar
  15. Werner, G. H., 1987, Natural and synthetic peptides (other than neuropeptides) endowed with immunomodulating activities, Immunology Letters, 16:363.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • G. Antoni
    • 1
  • R. Presentini
    • 1
  • F. Perin
    • 1
  • L. Nencioni
    • 1
  • L. Villa
    • 1
  • S. Censini
    • 1
  • P. Ghiara
    • 1
  • G. Volpini
    • 1
  • P. Bossu’
    • 1
  • A. Tagliabue
    • 1
  • D. Boraschi
    • 1
  1. 1.Sclavo Research CenterSienaItaly

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