In Vitro Studies on Docosahexaenoic Acid in Human Platelets

  • M. Lagarde
  • M. Croset
  • M. Hajarine


Arachidonic acid (5,8,11,14–20:4 or 20:4w6) is the main polyunsaturated fatty acid of blood and vascular cells and it has been recognized as the precursor of numerous oxygenated derivatives exhibiting a variety of biological activities (1 – 3). In blood platelets, 20:4w6 is almost exclusively located in glycerophospholipids, from where it is fastly mobilized upon cell activation by aggregating agents like thrombin, collagen or the calcium ionophore A 23187 (4–6). Such a mobilization is the limiting step of prostaglandin endoperoxides and thromboxane A2 formation, the potent proaggregatory molecules, as well as of that of 12-lipoxygenase products.


Docosahexaenoic Acid Human Platelet Prostaglandin Endoperoxide Lipoxygenase Product Polyenoic Acid 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • M. Lagarde
    • 1
  • M. Croset
    • 1
  • M. Hajarine
    • 1
  1. 1.INSERM U 205, INSA B 406Villeurbanne CedexFrance

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