(N-3) and (N-6) Fatty Acid Metabolism
Dietary (n−3) fatty acids mediate physiological processes in at least two different ways. The activities of the liver enzymes that metabolize fatty acids and synthesize triglycerides are modified by the type of fat that is fed. These changes include an elevated rate of fatty acid oxidation along with a reduced rate of fatty acid biosynthesis1,2. The mechanism of action of (n−3) acids at the enzyme level is still a matter of conjecture. Clarke and Armstrong3 have recently reported that rats fed a fish oil diet had reduced levels of mRNA for fatty acid synthetase. These findings suggest that (n−3) fatty acids, or one of their metabolites, regulate enzyme synthesis rather than enzyme activity.
KeywordsHuman Platelet Hydroxy Fatty Acid Chain Elongation Fatty Acid Synthetase Eicosatetraenoic Acid
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