Selective Incorporation of Eicosapentaenoic Acid in Position 2 of Plasma Triglycerides after a Dietary Supply of 2 Eicosapentaenoyl Glyceride in Man

  • B. Descomps
  • S. El Boustani
  • L. Monnier
  • F. Mendy
  • A. Crastes de Paulet

Abstract

The chemical form of polyunsaturated fatty acids (PUFA) in dietary sources is an essential determinant for their absorption and bio-availability. For example, we recently showed in man that enteral absorption of eicosapentaenoic acid (EPA) is higher and rapid when EPA is ingested as free fatty acid or triglyceride but is low when EPA is ingested as ethylester (1). This result was recently confirmed (2). Moreover, the ingestion of a synthetic triglyceride carrying EPA in position two, 1,3-dioctanoyl-2-eicosapentaenoyl glycerol (2EPA) is followed by a high incorporation of EPA in plasma triglycerides (1).

Keywords

Eicosapentaenoic Acid Plasma Triglyceride Pancreatic Lipase Porcine Pancreatic Lipase Free Fatty Acid Fraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    El Boustani S., C.Colette, L.Monnier, B.Descomps, A.Crastes de Paulet, F.Mendy (1987) Enteral absorption in man of eicosapentaenoic acid in different chemical forms, Lipids 22, 711Google Scholar
  2. 2.
    Lawson L.D. and B.G.Hugues (1988) Human absorption of fish oil fatty acids as triacylglycerols, free acids or ethyl esters, Biochem. Biophys.Res.Com. 152 328Google Scholar
  3. 3.
    El Boustani S., B.Descomps, L.Monnier, J.Warnant, F.Mendy, A.Crastes de Paulet (1986) In vivo conversion of dihomogamma linolenic acid in man, Prog.Lipid Res. 25, 67.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • B. Descomps
    • 1
  • S. El Boustani
    • 1
  • L. Monnier
    • 1
  • F. Mendy
    • 1
  • A. Crastes de Paulet
    • 1
  1. 1.INSERM U.58; Laboratoire Biochemie AService des Maladies Metaboliques et Endocriniennes du CHRMontpellierFrance

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