Different Doses of Fish — Oil Fatty Acid Ingestion in Active Rheumatoid Arthritis: A Prospective Study of Clinical and Immunological Parameters

  • Joel M. Kremer
  • David A. Lawrence
  • William Jubiz


Lee, et al, have demonstrated that fish — oil ingestion leads to decreased production of leukotriene B4 (LTB4) derived from arachidonate through the 5-lipoxygenase pathway with the new production of leukotriene B5 (LTB5) from EPA(1). Since LTB4 is a potent inflammatory and chemotactic compound, a decrease in its production could favorably affect the clinical manifestations of an inflammatory disease like rheumatoid arthritis. It was not surprising, then, when we observed improvement in certain clinical manifestations of rheumatoid arthritis which were significantly correlated with decreased production of neutrophil LTB4 in patients receiving fish — oil(2).


Active Rheumatoid Arthritis Rheumatic Drug Albany Medical College Rheumatoid Synovial Cell Intraarticular Steroid Injection 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Joel M. Kremer
    • 1
  • David A. Lawrence
    • 1
  • William Jubiz
    • 1
  1. 1.Division of Rheumatology, Department of Microbiology/ImmunologyAlbany Medical College and Albany Veteran’s Administration HospitalAlbanyUSA

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