Abstract
The two main dietary essential fatty acids (EFAs) are linoleic acid and alpha-linolenic acid (ALA). These two parent fatty acids are metabolized within the body to whar are sometimes called the derived EFAs. The derived EFAs include gamma-linolenic acid (GLA), dihomogammalinolenic acid (DGLA) and arachidonic acid of the n−6 series from linoleic acid, and eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) of the n−3 series from ALA. The traditional teaching is that there is no dietary requirement for the derived EFAs. It is assumed that all the amounts of the derived EFAs that are needed can be formed within the body from linoleic acid and ALA.
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References
Hudson, B.J.F., Human Nutrition: Food Sci. Nutr. 41F: 1 (1987)
Kummerow, F.A., J. Environ. Path. Toxicol. Chem. 6: 123 (1986)
Brenner, R.R., Progr. Lipid Res. 20: 41 (1982)
Garcia, P.T. and Holman, R.T., J. Am. Oil Chem. Soc. 42: 1137 (1965).
Sprecher, H., Progr. Lipid Res. 20: 13 (1982).
Manku, M.S., Horrobin, D.F., Morse, N.L., Wright, S. and Burton, J.L., Br. J. Dermatol. 110: 643 (1984).
Strannegard, I.L., Svennerholm, L. and Strannegard, O., Int. Arch. Allergy Appl. Immunol. 82: 423 (1987).
Jones, D.B., Carter, R.D., Haitas, B. and Mann, J.I., Br. Med. J. 286: 178 (1983).
Tilvis, R.S., Helve, E. and Miettinen, T.A., Diabetologia 29: 690 (1986).
Glen, I., Skinner, F., Glen, E. and MacDonell, L., Alcoholism: Clin. Exp. Res. 11: 37 (1987).
Putnam, J.C., Carlson, S.E., DeVoe, P.W. and Barness, L.A., Am. J. Clin. Nutr. 36: 106, 1982.
Miettinen, T.A., Huttunen, J.K., Naukkarinen, V., Monogr. Atherosclerosis 4: 19 (1986).
Salonen, J.T., Salonen, R. and Penttila, I., Am. J. Cardiol. 58: 226, (1985).
Wood, D.A., Butler, S. and Riemersma, R.A., Lancet 2: 117 (1984).
Bates, C. van Dam, C. and Horrobin, D.F., Prostaglandins Leukotr. Med. 17: 77 (1985).
Horrobin, D.F., Med. Hypotheses 22: 421 (1987).
Frankel, T.L. and Rivers, J.P.W., Br. J. Nutr. 39: 227 (1978).
Manku, M.S., Morse-Fisher, N. and Horrobin, D.F., Eur. J. Clin. Nutr. 42: 55 (1988).
Gibson, R.A., Sinclair, A.J., Comp. Biochem. Physiol. 78C: 325 (1984).
Qureshi, A.A., Schnoes, H.K., Din, Z.Z. and Peterson, D.M., Fed. Proc. 43: 2626 (1984).
Hudson, B.J.F. J. Am. Oil Chem. Soc. 61: 540 (1984).
Traitler, H. and Winter, H., Progr. Lipid Res. 25: 255 (1986).
Wright, S. and Burton, J.L., Lancet 2: 1120 (1982).
Belch, J.J.F., Ansell, D., Madhok, R., O’Dowd, A. and Sturrock, R.D., Ann. Rheum. Dis. 47: 96 (1988).
Jamal, G.A., Carmichael, H. and Weir, A.J., Lancet 1: 1098 (1986).
Glen, E., MacDonnell, L., Glen, I. and MacKenzie, J. Possible pharma-cological approaches to the prevention and treatment of alcohol-related CNS impairment: results of a double blind trial of essential fatty acid, in Pharmacological Treatments for Al oholism, G. Edwards and J. Littleton, eds., Croom Helm, London.
Pye, J.K., Mansel, R.E. and Hughes, L.E., Lancet 2: 373 (1985).
Dayton, S., Hashimoto, S. and Dixon, W. J., Lipid. Res. 7: 103 (1966).
Singer, P., Berger, I. & Wirth, M., Prostaglandins Leukotr. Med. 24: 173 (1986).
Singer, P., Jaeger, W. and Voigt, S., Prostaglandins Leukotr. Med. 15: 159 (1984).
Lasserre, M., Mendy, F. and Spielman, D., Lipids 20: 227–233 (1985).
Gibson, R.A., Proc. Nutr. Soc. Australia 10: 196 (1985).
Vericel, E., Lagarde, M., Mendy, F., Courpron, P. and Dechavanne, M., Nutr. Res. 7: 569 (1987).
Manku, M.S., Morse-Fisher, N. and Horrobin, D.F., Eur. J. Clin. Nutr. 42: 55 (1988).
Everett, D.J., Greenough, R.J., Perry, C.J., McDonald, P. and Bayliss, P. Med. Sci. Res. in press.
Perry, C.J., Everett, D.J., Macnaughten, F., Howroyd, P. and Bayliss, P., Med. Sci. Res. in press.
Schalin-Karrila, M., Mattila, L., Jansen, C.T. and Uotila, P., Br. J. Dermatol. 117: 11, 1987.
Morse, P.F., Horrobin, D.F., Manku, M.S. and Stewart, J.C.M., Br. J. Dermatol. in press.
Poisson, J.P., Enzyme 34: 1 (1985).
Horrobin, D.F., Prostaglandins Leukotr. EFAs 31: 181 (1988).
Jamal, G.A., Carmichael, H. and Weir, A.J., Lancet 1: 1098 (1986).
Brush, M.G., Watson, S.J., Horrobin, D.F. and Manku, M.S., Am. J. Obstet. Gynecol. 150: 363 (1984).
Puolakka, J., Makarainen, L., Viinikka, L. and Ylikorkala, O. J., Re-prod. Med. 30: 149 (1985).
Massil, H., O’Brien, P.M.S. and Brush, M.G., presented at 2nd International Symposium on Premenstrual Syndrome, Kiawah Island, Sept. 1987.
Casper, R., presented at 2nd International Symposium on Premenstrual Syndrome, Kiawah Island, Sept. 1987.
Oeckermann, P.A., Bachrack, I., Glans, S. and Rassner, S., Rec. Adv. Clin. Nutr. 2: 404 (1986).
Horrobin, D.F. J., Reprod. Med. 30: 149 (1985).
Horrobin, D.F. and Manku, M.S., presented at 2nd International Symposium on Premenstrual Syndrome, Kiawah Island, Sept. 1987.
Kunkel, S.L., Ogawa, H., Ward, P.A. and Zurier, R.B., Progr. Lipid Res. 20: 885, 1981.
Hansen T.M., Lerche, A., Kassis, V., Lorenzen, I. and Sondergaard, J., Scand. J. Rheumatol. 12: 85 (1983).
Lawson, L.D. and Hughes, B.G., Biochem. Biophys. Res. Comm. 152: 328 (1988).
Myher, J.J., Marai, A., Kuksis, A. and Kritchevsky, D., Lipids 12: 775 (1977).
Lawson, L.D. and Hughes, B.G., Lipids 23: 313 (1988).
Jenkins, D.K. Mitchell, J.C., Manku, M.S. and Horrobin, D.F., Med. Sci. Res. in press.
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Horrobin, D.F. (1989). Polyunsaturated Oils of Marine and Plant Origins and Their Uses in Clinical Medicine. In: Galli, C., Simopoulos, A.P. (eds) Dietary ω3 and ω6 Fatty Acids. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2043-3_27
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DOI: https://doi.org/10.1007/978-1-4757-2043-3_27
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